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This prospective cohort study included 40 adolescents, ages 14 and 15, without substantial history of alcohol or drug use at baseline. Fractional anisotropy (FA), an index of white\u2010matter microstructure, was assessed in pathways connecting the nucleus accumbens (NAcc) to the rest of the brain using diffusion tensor imaging. Path analyses were conducted voxel\u2010wise within these pathways to examine direct effects of premorbid FA on number of months between baseline assessment and the onset of binge drinking and indirect effects mediated by NAcc activation during decision making assessed using functional magnetic resonance imaging. Adolescents with lower premorbid accumbofrontal FA began binge drinking sooner, an effect which was mediated by greater NAcc activation during decision making involving greater levels of risk and reward (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 corrected). An additional direct effect of FA on duration to onset of binge drinking was observed in white matter near the ventral pallidum, as adolescents with lower premorbid FA in this region began binge drinking sooner (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 corrected). Findings suggest that delayed maturation of prefrontal white\u00a0matter is associated with less top\u2010down control over striatal sensitivity to reward. These factors, along with individual differences in white matter proximal to ventral pallidum, may represent premorbid risk factors for earlier initiation of heavy alcohol use.<\/jats:p>","DOI":"10.1111\/adb.12767","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T04:48:52Z","timestamp":1558068532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking"],"prefix":"10.1111","volume":"25","author":[{"given":"Angelica M.","family":"Morales","sequence":"first","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Patching\u2010Bunch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-7453","authenticated-orcid":false,"given":"Bonnie J.","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health and Science University  Portland OR USA"},{"name":"Department of Behavioral Neuroscience Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1176"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2014.989353"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-3289(97)90009-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.01.024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010213-115159"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074164"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci2040605"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0087-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.129"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00953.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.01.058"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200104000-00013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1998.59.427"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2014.07.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2015.06.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.01.044"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0315-x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(96)01263-X"},{"key":"e_1_2_7_23_1","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"Wechsler D","year":"1999"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2089217"},{"issue":"4","key":"e_1_2_7_25_1","first-page":"995","article-title":"The Children's Depression, Inventory (CDI)","volume":"21","author":"Kovacs M","year":"1985","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_7_26_1","unstructured":"National Institue on Alcohol Abuse and Alcoholism.Drinking Levels Defined.2018.https:\/\/www.niaaa.nih.gov\/alcohol\u2010health\/overview\u2010alcohol\u2010consumption\/moderate\u2010binge\u2010drinking. 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