{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:11:01Z","timestamp":1787163061068,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K05 AA017435"],"award-info":[{"award-number":["K05 AA017435"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Proton magnetic resonance spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS) studies have demonstrated abnormal levels of a variety of neurometabolites in treatment\u2010seeking individuals with moderate\u2010severe alcohol use disorder (AUD) following acute withdrawal. In contrast, few studies have investigated neurochemical changes across early abstinence in less severe, treatment\u2010na\u00efve AUD. The present study, which represents the primary report of a research grant from ABMRF\/The Alcohol Research Fund, measured dorsal anterior cingulate cortex (dACC) GABA, glutamate, and glutamine levels in treatment\u2010na\u00efve AUD (n = 23) via three\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS scans spaced across a planned week of abstinence from alcohol. In addition to AUD participants, 12 light drinkers completed two scans, separated by 48 hours, to ensure that results in AUD were not produced by between\u2010scan differences other than abstinence from alcohol.\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS spectra were acquired in dACC at each scan using 2D\n                    <jats:italic>J<\/jats:italic>\n                    \u2010resolved point\u2010resolved spectroscopy. Linear mixed modeling results demonstrated a significant increase in GABA, but not glutamate or glutamine (\n                    <jats:italic>P<\/jats:italic>\n                    s = .237\u2010.626), levels between scans 1 and 2 (+8.88%, .041), with no difference between scans 2 and 3 (+1.00%, .836), in AUD but not LD (\n                    <jats:italic>F<\/jats:italic>\n                    = 1.24, .290) participants. Exploratory regression analyses tentatively revealed a number of significant prospective associations between changes in glutamine levels and heavy drinking, craving, and withdrawal symptoms. Most notably, the present study demonstrated return from abnormally low to normal GABA levels in treatment\u2010na\u00efve AUD within 3 days of their last drink; the pattern of results was consistent with glutamate and glutamine disturbances being exclusive to relatively more severe AUD.\n                  <\/jats:p>","DOI":"10.1111\/adb.12810","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T20:54:51Z","timestamp":1564692891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment\u2010naive individuals with alcohol use disorder"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-7871","authenticated-orcid":false,"given":"James J.","family":"Prisciandaro","sequence":"first","affiliation":[{"name":"Department of Psychiatry and 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