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Previous work revealed that mice with a global or cell\u2010specific knockout of \u03b2arr2 have altered responses to certain drugs; however, the effects of \u03b2arr2 on the excitability of medium spiny neurons (MSNs), and its role in mediating the rewarding effects of drugs of abuse are unknown. D1\u2010Cre and D2\u2010Cre transgenic mice were crossed with floxed \u03b2arr2 mice to eliminate \u03b2arr2 specifically in cells containing either D1 (D1\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    ) or D2 (D2\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    ) receptors. We used slice electrophysiology to characterize the role of \u03b2arr2 in modulating D1 and D2 nucleus accumbens MSN intrinsic excitability in response to DA and tested the locomotor\u2010activating and rewarding effects of cocaine and morphine in these mice. Eliminating \u03b2arr2 attenuated the ability of DA to inhibit D2\u2010MSNs and altered the DA\u2010induced maximum firing rate in D1\u2010MSNs. While D1\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    mice had mostly normal drug responses, D2\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    mice showed dose\u2010dependent reductions in acute locomotor responses to cocaine and morphine, attenuated locomotor sensitization to cocaine, and blunted cocaine reward measured with conditioned place preference. Both D2\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    and D1\n                    <jats:sup>\u03b2arr2\u2010KO<\/jats:sup>\n                    mice displayed an enhanced conditioned place preference for the highest dose of morphine. These results indicate that D1\u2010 and D2\u2010derived \u03b2arr2 functionally contribute to DA\u2010induced changes in MSN intrinsic excitability and behavioral responses to psychostimulants and opioids dose\u2010dependently.\n                  <\/jats:p>","DOI":"10.1111\/adb.12823","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T04:50:26Z","timestamp":1566535826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Loss of \u03b2\u2010arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-8641","authenticated-orcid":false,"given":"Kirsten A.","family":"Porter\u2010Stransky","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Western Michigan University Homer Stryker M.D. School of Medicine  Kalamazoo MI USA"},{"name":"Department of Human Genetics Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa K.","family":"Petko","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio Neuroscience Institute, Department ofBiology University of Texas at San Antonio  San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumya L.","family":"Karne","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Cameron","family":"Liles","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil M.","family":"Urs","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Department of Cell Biology  Durham NC USA"},{"name":"Department of Pharmacology and Therapeutics University of Florida College of Medicine  Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc G.","family":"Caron","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Department of Cell Biology  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Paladini","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio Neuroscience Institute, Department ofBiology University of Texas at San Antonio  San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-6215","authenticated-orcid":false,"given":"David","family":"Weinshenker","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5274"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.04.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.713313"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.240622"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10265.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614347113"},{"issue":"35","key":"e_1_2_8_10_1","first-page":"35","article-title":"Chronic loss of noradrenergic tone produces \u03b2\u2010arrestin2\u2010mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens","volume":"21","author":"Gaval\u2010Cruz M","year":"2014","journal-title":"Addict Biol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4068"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12253"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010213-115159"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2016.01.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2822-18.2018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.186"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.254"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502742112"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0371-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301000"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12709"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2225-08.2008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.040"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-09-03334.1997"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","unstructured":"SurmeierD KitaiS.D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons. 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