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The current study assessed the effects of acute, infant ELS on alcohol drinking, including aversion\u2010resistant drinking, in male and female Long Evans rats. Acute ELS was induced using a stress\u2010enhanced fear learning (SEFL) protocol that consisted of 15 footshocks delivered on postnatal day (PND) 17. Alcohol drinking during adolescence and adulthood was measured with a two\u2010bottle choice intermittent alcohol access paradigm. Aversion\u2010resistant drinking was assessed in adulthood by adding quinine (0.01, 0.1, and 1.0 g\/L) to the alcohol bottle after 5 to 6 weeks and 11 to 12 weeks of drinking. ELS had minimal influences on adolescent and adult alcohol consumption and preference. However, ELS, sex, and alcohol exposure history all influenced aversion\u2010resistant alcohol drinking in an additive fashion. Higher concentrations of quinine were tolerated in females, ELS\u2010exposed rats, and after 11 to 12 weeks of drinking. Tests of quinine sensitivity in a separate cohort of animals found that rats can detect concentrations of quinine as low as 0.001 g\/L in water and that quinine sensitivity is not influenced by sex or ELS exposure. These results agree with reports of sex differences in aversion\u2010resistant drinking and are the first to demonstrate an influence of ELS on this behavior. Our results also suggest that a single traumatic stress exposure in infancy may be a promising model of comorbid PTSD and AUD and useful in studying the interactions between ELS, sex, and alcohol dependence.<\/jats:p>","DOI":"10.1111\/adb.12829","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T01:39:28Z","timestamp":1572226768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Additive influences of acute early life stress and sex on vulnerability for aversion\u2010resistant alcohol drinking"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-7580","authenticated-orcid":false,"given":"Anna K.","family":"Radke","sequence":"first","affiliation":[{"name":"Department of Psychology and Center for Neuroscience and Behavior Miami University  Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel T.","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Psychology and Center for Neuroscience and Behavior Miami University  Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Sneddon","sequence":"additional","affiliation":[{"name":"Department of Psychology and Center for Neuroscience and Behavior Miami University  Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin A.","family":"Riddle","sequence":"additional","affiliation":[{"name":"Department of Psychology and Center for Neuroscience and Behavior Miami University  Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-4901","authenticated-orcid":false,"given":"Jennifer J.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Psychology and Center for Neuroscience and Behavior Miami University  Oxford Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Association AP Others.Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae). 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