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We previously demonstrated that cocaine\u2010induced conditioned preference increased activity at the dorsal posterior cerebellar vermis. Unexpectedly, a neurotoxic lesion at this region increased the probability of cocaine\u2010induced conditioned preference acquisition. The present research aimed at providing an explanatory model for such as facilitative effect of the cerebellar lesion. First, we addressed a tracing study in which we found a direct projection from the lateral (dentate) nucleus to the ventral tegmental area (VTA) that also receives Purkinje axons from lobule VIII in the vermis. This pathway might control the activity and plasticity of the cortico\u2010striatal circuitry. Then we evaluated cFos expression in different regions of the medial prefrontal cortex and striatum after a lesion in lobule VIII before conditioning. Additionally, perineuronal net (PNN) expression was assessed to explore whether the cerebellar lesion might affect synaptic stabilization mechanisms in the medial prefrontal cortex (mPFC). Damage in this region of the vermis induced general disinhibition of the mPFC and striatal subdivisions that receive dopaminergic projections, mainly from the VTA. Moreover, cerebellar impairment induced an upregulation of PNN expression in the mPFC. The major finding of this research was to provide an explanatory model for the function of the posterior cerebellar vermis on drug\u2010related memory. In this model, damage of the posterior vermis would release striatum\u2010cortical networks from the inhibitory tonic control exerted by the cerebellar cortex over VTA, thereby promoting drug effects.<\/jats:p>","DOI":"10.1111\/adb.12834","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T11:41:46Z","timestamp":1575632506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine\u2010related cues"],"prefix":"10.1111","volume":"26","author":[{"given":"Isis","family":"Gil\u2010Miravet","sequence":"first","affiliation":[{"name":"\u00c1rea de Psicobiolog\u00eda Universitat Jaume I  Castell\u00f3n de la Plana 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