{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:19:33Z","timestamp":1778901573420,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016506","name":"Alcohol and Drug Abuse Institute, University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With legalization efforts across the United States, cannabis use is becoming increasingly mainstream. Various studies have documented the effects of acute and chronic cannabis use on brain structure and cognitive performance, including within the frontal executive control network, but little attention has been given to the effects on the cerebellum. Recent evidence increasingly points to the role of the cerebellum in various nonmotor networks, and the cerebellum's expression of cannabinoid receptors may pose particular vulnerabilities to the consequences of cannabis use. Using a combined approach of resting\u2010state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), the present study aims to assess how cannabis use relates to the cerebellum's intrinsic functional connectivity and underlying white matter structure and whether these properties are associated with craving or severity of cannabis use. Resting\u2010state fMRI and DTI data, as well as self\u2010reports of substance use history, were analyzed from a sample of 26 adults at risk for cannabis use disorder (CUD) and an age\u2010 and sex\u2010matched comparison group of 25 cannabis\u2010na\u00efve adults (control). Results demonstrated that individuals at risk for a CUD showed key differences in cerebellar functional connectivity, with specific impacts on the dorsal attention and default mode networks. In addition, group differences in white matter were localized to the middle cerebellar peduncle (MCP), with a relationship between lower MCP diffusivity and higher levels of self\u2010reported craving. These findings lend further support to the cerebellum's role in key cognitive networks and potential consequences for substance use disorders.<\/jats:p>","DOI":"10.1111\/adb.12839","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T04:45:41Z","timestamp":1575866741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A multimodal investigation of cerebellar integrity associated with high\u2010risk cannabis use"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-2602","authenticated-orcid":false,"given":"Julia","family":"Sweigert","sequence":"first","affiliation":[{"name":"Department of Radiology University of Washington  Seattle Washington"},{"name":"Integrated Brain Imaging Center University of Washington  Seattle 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