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Previous studies have pointed out to the dopamine D1 receptor as one major player in psychostimulants\u2010induced behavioral, cellular, and molecular changes. However, the role of other dopamine receptors has not been fully characterized. Here we used dopamine D2 receptor knockout (D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice to explore the role of D2 receptor (D2R) in behavioral sensitization and its associated gene expression after acute and chronic cocaine and amphetamine administration. We also studied the impact of D2R elimination in D1R\u2010mediated responses. We found that cocaine\u2010 and amphetamine\u2010induced behavioral sensitization is deficient in D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. The expression of dynorphin, primarily regulated by D1R and a marker of direct\u2010pathway striatal neurons, is attenuated in na\u00efve\u2010 and in cocaine\u2010 or amphetamine\u2010treated D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Moreover, c\u2010Fos expression observed in D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice was reduced in acutely but not in chronically treated animals. Interestingly, inactivation of D2R increased c\u2010Fos expression in neurons of the striatopallidal pathway. Finally, elimination of D2R blunted the locomotor and striatal c\u2010Fos response to the full D1 agonist SKF81297. In conclusion, D2R is critical for the development of behavioral sensitization and the associated gene expression, after cocaine administration, and it is required for the locomotor responses promoted by D1R activation.\n                  <\/jats:p>","DOI":"10.1111\/adb.12840","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T22:31:00Z","timestamp":1576189860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-5891","authenticated-orcid":false,"given":"Oscar","family":"Sol\u00eds","sequence":"first","affiliation":[{"name":"Instituto Cajal Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"},{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Garc\u00eda\u2010Sanz","sequence":"additional","affiliation":[{"name":"Instituto Cajal Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"},{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Instituto Cajal Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Granado","sequence":"additional","affiliation":[{"name":"Instituto Cajal Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"},{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Sanz\u2010Magro","sequence":"additional","affiliation":[{"name":"Instituto Cajal Consejo Superior de Investigaciones Cient\u00edficas Madrid Spain"},{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Podlesniy","sequence":"additional","affiliation":[{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Trullas","sequence":"additional","affiliation":[{"name":"CIBERNED Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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