{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:52:37Z","timestamp":1775872357347,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 1519"],"award-info":[{"award-number":["GRK 1519"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE2597\/15\u20101"],"award-info":[{"award-number":["HE2597\/15\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE2597\/15\u20102"],"award-info":[{"award-number":["HE2597\/15\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While an increased impact of cues on decision\u2010making has been associated with substance dependence, it is yet unclear whether this is also a phenotype of non\u2010substance\u2010related addictive disorders, such as gambling disorder (GD). To better understand the basic mechanisms of impaired decision\u2010making in addiction, we investigated whether cue\u2010induced changes in decision\u2010making could distinguish GD from healthy control (HC) subjects. We expected that cue\u2010induced changes in gamble acceptance and specifically in loss aversion would distinguish GD from HC subjects.<\/jats:p>\n                  <jats:p>Thirty GD subjects and 30 matched HC subjects completed a mixed gambles task where gambling and other emotional cues were shown in the background. We used machine learning to carve out the importance of cue dependency of decision\u2010making and of loss aversion for distinguishing GD from HC subjects.<\/jats:p>\n                  <jats:p>\n                    Cross\u2010validated classification yielded an area under the receiver operating curve (AUC\u2010ROC) of 68.9% (\n                    <jats:italic>p<\/jats:italic>\n                    = .002). Applying the classifier to an independent sample yielded an AUC\u2010ROC of 65.0% (\n                    <jats:italic>p<\/jats:italic>\n                    = .047). As expected, the classifier used cue\u2010induced changes in gamble acceptance to distinguish GD from HC. Especially, increased gambling during the presentation of gambling cues characterized GD subjects. However, cue\u2010induced changes in loss aversion were irrelevant for distinguishing GD from HC subjects. To our knowledge, this is the first study to investigate the classificatory power of addiction\u2010relevant behavioral task parameters when distinguishing GD from HC subjects. The results indicate that cue\u2010induced changes in decision\u2010making are a characteristic feature of addictive disorders, independent of a substance of abuse\n                  <\/jats:p>","DOI":"10.1111\/adb.12841","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T05:35:01Z","timestamp":1573536901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cue\u2010induced effects on decision\u2010making distinguish subjects with gambling disorder from healthy controls"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-0709","authenticated-orcid":false,"given":"Alexander","family":"Genauck","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Bernstein Center for Computational Neuroscience Berlin  Berlin 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Information Processing, Technische Universit\u00e4t Berlin, Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Department of Psychology, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Kathmann","sequence":"additional","affiliation":[{"name":"Department of Psychology, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Romanczuk\u2010Seiferth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 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