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The abuse potential of 3\u2010FMA has not been fully characterized. The aim of this study was to evaluate the effects of 3\u2010FMA on locomotor activity as well as its rewarding and reinforcing properties in the conditioned place preference (CPP) and self\u2010administration procedures. Intravenous (i.v.) administration of 3\u2010FMA (0.5 and 1.0 mg\/kg) significantly increased locomotor activity in a dose\u2010dependent manner in rats. In the CPP procedure, intraperitoneal administration of 3\u2010FMA (10 and 30 mg\/kg) produced a significant alteration in place preference in mice. In the self\u2010administration paradigms, 3\u2010FMA showed drug\u2010taking behavior at the dose of 0.1 mg\/kg\/infusion (i.v.) during 2 hr sessions under fixed ratio schedules and high breakpoints at the dose of 0.3 and 1.0 mg\/kg\/infusion (i.v.) during 6 hr sessions under progressive ratio schedule of reinforcement in rats. A priming injection of 3\u2010FMA (0.4 mg\/kg, i.v.), METH (0.2 mg\/kg, i.v.), or cocaine (2.0 mg\/kg, i.v.) reinstated 3\u2010FMA\u2010seeking behavior after an extinction period in 3\u2010FMA\u2010trained rats during 2 hr session. Taken together, these findings demonstrate robust psychomotor, rewarding and reinforcing properties of 3\u2010FMA, which may underlie its potential for compulsive use in humans.<\/jats:p>","DOI":"10.1111\/adb.12846","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T08:25:33Z","timestamp":1575447933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The potent psychomotor, rewarding and reinforcing properties of 3\u2010fluoromethamphetamine in rodents"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-9326","authenticated-orcid":false,"given":"In Soo","family":"Ryu","sequence":"first","affiliation":[{"name":"Research Center for Convergence Toxicology Korea Institute of Toxicology  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong 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