{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:22:01Z","timestamp":1790511721676,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA039903"],"award-info":[{"award-number":["R01 DA039903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA10788"],"award-info":[{"award-number":["R01 AA10788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gray matter (GM) atrophy associated with alcohol use disorders (AUD) affects predominantly the frontal lobes. Less is known how frontal lobe GM loss affects GM loss in other regions and how it influences drinking behavior or relapse after treatment. The profile similarity index (PSI) combined with graph analysis allows to assess how GM loss in one region affects GM loss in regions connected to it, ie, GM connectivity. The PSI was used to describe the pattern of GM connectivity in 21 light drinkers (LDs) and in 54 individuals with AUD (ALC) early in abstinence. Effects of abstinence and relapse were determined in a subgroup of 36 participants after 3 months. Compared with LD, GM losses within the extended brain reward system (eBRS) at 1\u2010month abstinence were similar between abstainers (ABST) and relapsers (REL), but REL had also GM losses outside the eBRS. Lower GM connectivities in ventro\u2010striatal\/hypothalamic and dorsolateral prefrontal regions and thalami were present in both ABST and REL. Between\u2010networks connectivity loss of the eBRS in ABST was confined to prefrontal regions. About 3 months later, the GM volume and connectivity losses had resolved in ABST, and insula connectivity was increased compared with LD. GM losses and GM connectivity losses in REL were unchanged. Overall, prolonged abstinence was associated with a normalization of within\u2010eBRS connectivity and a reconnection of eBRS structures with other networks. The re\u2010formation of structural connectivities within and across networks appears critical for cognitive\u2010behavioral functioning related to the capacity to maintain abstinence after outpatient treatment.<\/jats:p>","DOI":"10.1111\/adb.12860","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T15:46:20Z","timestamp":1576856780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The gray matter structural connectome and its relationship to alcohol relapse: Reconnecting for recovery"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-4432","authenticated-orcid":false,"given":"Susanne G.","family":"Mueller","sequence":"first","affiliation":[{"name":"Center for imaging of Neurodegenerative Diseases VAMC San Francisco  San Francisco California"},{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter J.","family":"Meyerhoff","sequence":"additional","affiliation":[{"name":"Center for imaging of Neurodegenerative Diseases VAMC San Francisco  San Francisco California"},{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01831.x"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"127","article-title":"Alcohol's effects on brain and behavior","volume":"33","author":"Sullivan EV","year":"2010","journal-title":"Alcohol Res Health"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00407.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22132"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1141"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.01.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01452.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10020233"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2026"},{"issue":"4","key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/WCO.0b013e32833aa567","article-title":"Graph theoretical modeling of brain connectivity","volume":"23","author":"He Y","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3554-12.2013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr221"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.06.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00418"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24325"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101888"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","unstructured":"MeyerhoffDJ DurazzoTC.Modeling cognitive and neurobiological recovery in addiction. 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