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Evidence for aberrant functional connectivity between the striatum, insula, and frontal cortex in alcohol users exists at rest, but not during cue\u2010exposure. In this study, we investigated functional connectivity changes during a cue\u2010reactivity task across different subgroups of alcohol consumers. Ninety\u2010six participants (ranging from light social to heavy social drinkers and nonabstinent dependent to abstinent dependent drinkers) were examined. A functional magnetic resonance imaging cue\u2010reactivity paradigm was administered, during which alcohol\u2010related and neutral stimuli were presented. Applying psychophysiological interaction analyses, we found: (a) Abstinent alcohol\u2010dependent patients compared with non\u2010abstinent dependent drinkers showed a greater increase of functional connectivity of the ventral striatum and anterior insula with the anterior cingulate cortex and dorsolateral prefrontal cortex during the presentation of alcohol cues compared with neutral cues. (b) Subjective craving correlated positively with functional connectivity change between the posterior insula and the medial orbitofrontal cortex and negatively with functional connectivity change between the ventral striatum and the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex. (c) Compulsivity of alcohol use correlated positively with functional connectivity change between the dorsolateral prefrontal cortex and the ventral striatum, anterior insula, and posterior insula. Results suggest increased cognitive control over cue\u2010processing in abstinent alcohol\u2010dependent patients, compensating high levels of cue\u2010provoked craving and compulsive use.<\/jats:p><jats:p><jats:bold>Clinical trial registration details:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> ID: NCT00926900<\/jats:p>","DOI":"10.1111\/adb.12863","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T07:14:23Z","timestamp":1578381263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Investigation of brain functional connectivity to assess cognitive control over cue\u2010processing in Alcohol Use Disorder"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-7857","authenticated-orcid":false,"given":"Alicia","family":"Strosche","sequence":"first","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-0130","authenticated-orcid":false,"given":"Xiaochu","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China  Hefei Anhui China"},{"name":"Hefei Medical Research Center on Alcohol Addiction  Anhui Mental Health Center Hefei China"},{"name":"Academy of Psychology and Behavior Tianjin Normal University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derik","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ende","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-0398","authenticated-orcid":false,"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Vollst\u00e4dt\u2010Klein","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","unstructured":"Vollst\u00e4dt\u2010KleinS WichertS RabinsteinJ et al. Initial habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum.Addiction (Abingdon England). 2010;105:1741.","DOI":"10.1111\/j.1360-0443.2010.03022.x"},{"issue":"179","key":"e_1_2_11_3_1","article-title":"A triadic neurocognitive approach to addiction for clinical interventions","volume":"4","author":"No\u00ebl X","year":"2013","journal-title":"Frontiers in psychiatry."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12415"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.037"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.01.009"},{"issue":"182","key":"e_1_2_11_7_1","article-title":"Executive control and striatal resting\u2010state network interact with risk factors to influence treatment outcomes in alcohol\u2010use disorder","volume":"8","author":"Kohno M","year":"2017","journal-title":"Frontiers in psychiatry."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01859.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12037"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs190"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.11.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.08.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0291"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.04.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.034"},{"issue":"67","key":"e_1_2_11_16_1","article-title":"Neural circuitry of impulsivity in a cigarette craving paradigm","volume":"4","author":"Bourque J","year":"2013","journal-title":"Frontiers in psychiatry."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.134"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","unstructured":"KaagAM RenemanL HombergJ van denBrinkW vanWingenGA. 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