{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:40:49Z","timestamp":1778262049202,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione Banco di Sardegna 2017","award":["F71\/17000220002"],"award-info":[{"award-number":["F71\/17000220002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The bed nucleus of stria terminalis (BNST) is a complex limbic area involved in neuroendocrine and behavioural responses and, in particular, in the modulation of the stress response. BNST is innervated by dopamine and norepinephrine, which are known to be involved in drug addiction. It is also known that several drugs of abuse increase dopamine transmission in the BNST, but there has been less research regarding the effect on norepinephrine transmission. Here, we have used the microdialysis technique to investigate the effect of several drugs of abuse on norepinephrine transmission in the BNST of freely moving rats. We observed that nicotine (0.2\u20100.4 mg\/kg), cocaine (2.5\u20105 mg\/kg), amphetamine (0.25\u20100.5 mg\/kg), and ethanol (0.5\u20101.0 g\/kg), dose\u2010dependently increased norepinephrine output while the effect of morphine at 3.0 was lower than that of 1.0 mg\/kg. These results suggest that many drugs of abuse, though possessing diverse mechanisms of action, share the property of increasing norepinephrine transmission in the BNST. Furthermore, we suggest that the recurring activation of NE transmission in the BNST, due to drug administration, contributes to the alteration of the function that BNST assumes in how the behavioural response to stress manifests, favouring the establishment of the stress\u2010induced drug seeking.<\/jats:p>","DOI":"10.1111\/adb.12864","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T06:35:58Z","timestamp":1576650958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Nicotine, cocaine, amphetamine, morphine, and ethanol increase norepinephrine output in the bed nucleus of stria terminalis of freely moving rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Dragana","family":"Jadzic","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Bassareo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna R.","family":"Carta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-1937","authenticated-orcid":false,"given":"Ezio","family":"Carboni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.39"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033457"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.12.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.142"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.08.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.028"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890109014753"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000642"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1376-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90440-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.08.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.63"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750741.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.02.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3335-y"},{"key":"e_1_2_7_17_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0543-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20790"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-20-j0002.2000"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(86)90086-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09284.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000212"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971215)50:6<1040::AID-JNR15>3.0.CO;2-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3881"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.02.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2949-12.2013"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.178"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494799"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.02.015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.03.046"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06364.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91196-Y"},{"key":"e_1_2_7_35_1","first-page":"1188","article-title":"Nicotine\u2010induced norepinephrine release in the rat amygdala and hippocampus is mediated through brainstem nicotinic cholinergic receptors","volume":"284","author":"Fu Y","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03556.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301263"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.11.025"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90218-M"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00148-2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-j0006.1999"},{"key":"e_1_2_7_42_1","first-page":"42","article-title":"Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward","volume":"4","author":"Silberman Y","year":"2013","journal-title":"Front Psych"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.08.008"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.135"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1119311"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500307"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.032"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28720-6_143"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01326-2"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.241976"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.07.019"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02131.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903320102"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.07.011"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12123"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0680-14.2014"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905568107"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005298"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0425-04.2004"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.02.029"},{"key":"e_1_2_7_61_1","first-page":"2126","article-title":"The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse. Alcohol. 2012;46:303\u2010308Gungor NZ, Yamamoto R, Pare D. Glutamatergic and gabaergic ventral BNST neurons differ in their physiological properties and responsiveness to noradrenaline","volume":"43","author":"Kash TL","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.017"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:28:38Z","timestamp":1693870118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/adb.12864"],"URL":"https:\/\/doi.org\/10.1111\/adb.12864","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,17]]},"assertion":[{"value":"2019-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12864"}}