{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:41:34Z","timestamp":1793227294253,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR265"],"award-info":[{"award-number":["TRR265"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12\u2010year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism\u2010based interventions. These goals will be achieved by: (i) using mobile health (m\u2010health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real\u2010life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal\u2010directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.<\/jats:p>","DOI":"10.1111\/adb.12866","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T08:13:50Z","timestamp":1576829630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)\u2014From trajectories to mechanisms and interventions"],"prefix":"10.1111","volume":"25","author":[{"given":"Andreas","family":"Heinz","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-0398","authenticated-orcid":false,"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-5569","authenticated-orcid":false,"given":"Michael N.","family":"Smolka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Centre Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-8803","authenticated-orcid":false,"given":"Tanja","family":"Endrass","sequence":"additional","affiliation":[{"name":"Institute for Clinical Psychology and Psychotherapy Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beste","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-7295","authenticated-orcid":false,"given":"Anne","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-5734","authenticated-orcid":false,"given":"Shuyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-0709","authenticated-orcid":false,"given":"Alexander","family":"Genauck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Romund","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bermpohl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Deserno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Centre Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Max Planck Centre for Computational Psychiatry and Ageing Research &amp; Wellcome Centre for Human Neuroimaging University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Max Planck Centre for Computational Psychiatry and Ageing Research &amp; Wellcome Centre for Human Neuroimaging University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Durstewitz","sequence":"additional","affiliation":[{"name":"Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Ebner\u2010Priemer","sequence":"additional","affiliation":[{"name":"Department of Sports and Sports Science Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herta","family":"Flor","sequence":"additional","affiliation":[{"name":"Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Department of Psychology, School of Social Sciences University of Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita C.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Biobehavioral Health Pennsylvania State University  University Park Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derik","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim  Germany"},{"name":"Feuerlein Center on Translational Addiction Medicine (FCTS) University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiebel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Centre Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Department of Psychology and Neuroimaging Center Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-1248","authenticated-orcid":false,"given":"Peter","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Kirschbaum","sequence":"additional","affiliation":[{"name":"Department of Psychology, Biological Psychology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Koppe","sequence":"additional","affiliation":[{"name":"Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-0041","authenticated-orcid":false,"given":"Michael","family":"Marxen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Centre Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meyer\u2010Lindenberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Nagel","sequence":"additional","affiliation":[{"name":"Center for Information Services and High Performance Computing Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-247X","authenticated-orcid":false,"given":"Hamid R.","family":"Noori","sequence":"additional","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Max Planck Institute for Biological Cybernetics  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Pilhatsch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Priller","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry and Laboratory of Molecular Psychiatry Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"UK Dementia Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Rietschel","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Romanczuk\u2010Seiferth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim  Germany"},{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stallkamp","sequence":"additional","affiliation":[{"name":"Project Group for Automation in Medicine and Biotechnology Fraunhofer IPA  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Str\u00f6hle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-4020","authenticated-orcid":false,"given":"Ann\u2010Kathrin","family":"Stock","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Winterer","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Department of Anesthesiology and Intensive Care Medicine Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin (Campus Charit\u00e9 Mitte)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Vollst\u00e4dt\u2010Klein","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Rapp","sequence":"additional","affiliation":[{"name":"Social and Preventive Medicine Universit\u00e4t Potsdam  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Tost","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-4521","authenticated-orcid":false,"given":"Rainer","family":"Spanagel","sequence":"additional","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198506273122605"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-197604000-00002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95574911.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2010.129056"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2005.01065.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.022"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081086"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181e898d0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.12.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100662"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.0882"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0365-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12187"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.3\/rspanagel"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1635"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12278"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:39:32Z","timestamp":1694072372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/adb.12866"],"URL":"https:\/\/doi.org\/10.1111\/adb.12866","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"2019-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12866"}}