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Appropriate treatment for this life\u2010long disease has not been developed, and even diagnostic biomarkers are unavailable. FASD remains a large unmet medical need. Numerous animal models have been developed to mimic FASD and study potential underlying biological mechanisms. However, most of these models focused on neuronal phenotypes. Given that glial cells represent the majority of cells in the vertebrate brain, and given the increasingly appreciated roles they play in a myriad of neuronal functions as well as CNS disorders, we decided to investigate potential embryonic alcohol exposure induced changes in them. Building upon a previously introduced zebrafish model of milder and most prevalent forms of FASD, we investigated the effect of a 2\u2010hour\u2010long exposure to alcohol (1% vol\/vol bath concentration) employed at the 24<jats:sup>th<\/jats:sup> hour postfertilization stage of development of zebrafish on a number of glial cell\u2010related phenotypes. We studied oligodendrocyte, astrocyte as well as microglia\u2010related phenotypes using immunohistochemistry, lipid, and enzyme activity analyses. We report significant changes in wide\u2010spread glial cell phenotypes induced by embryonic alcohol exposure in the zebrafish brain and conclude that the zebrafish will advance our understanding of the mechanisms of this devastating disorder.<\/jats:p>","DOI":"10.1111\/adb.12867","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T01:00:51Z","timestamp":1578618051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lasting alterations induced in glial cell phenotypes by short exposure to alcohol during embryonic development in zebrafish"],"prefix":"10.1111","volume":"26","author":[{"given":"Dipashree","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Psychology University of Toronto Mississauga  Mississauga Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Mahabir","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diptendu","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto Mississauga  Mississauga Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-3859","authenticated-orcid":false,"given":"Robert","family":"Gerlai","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology University of Toronto  Toronto Canada"},{"name":"Department of Psychology University of Toronto Mississauga  Mississauga Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9166-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.1919"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.74"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00255-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.69"},{"key":"e_1_2_6_7_1","first-page":"447","article-title":"Long\u2010term behavioral changes in response to early developmental exposure to ethanol in zebrafish. 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