{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:34:53Z","timestamp":1792186493442,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HM14C2578"],"award-info":[{"award-number":["HM14C2578"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Internet gaming disorder (IGD) is a behavioral addiction involving excessive online game use despite negative psychosocial consequences. Unrestricted online gaming may lead to changes in striatal activity and the relationship between the striatum and other cortical regions. This study investigated structural and functional abnormalities involving the striatum through longitudinal follow\u2010up magnetic resonance imaging (MRI) assessments. Eighteen young males with IGD (mean age: 23.8 \u00b1 2.0 years) and 18 controls (mean age: 23.9 \u00b1 2.7 years) were evaluated. Subjects were reassessed \u22651 year after the first visit (mean follow\u2010up duration: 22.8 \u00b1 6.7 months), using voxel\u2010based morphometry and seed\u2010based resting\u2010state functional connectivity (FC) analyses in seed regions of the dorsal and ventral striatum. Subjects with IGD had smaller gray matter volume (GMV) in the anterior\/middle cingulate cortex compared with controls during initial and follow\u2010up assessments. They exhibited decreased FC between the left dorsal putamen and left medial prefrontal cortex (mPFC) compared with controls. They exhibited increased FC strength between the right dorsal putamen and right middle occipital gyrus (MOG) during follow\u2010up. Subjects with IGD showed a significant correlation between changes in the dorsal putamen\u2010MOG FC and gaming time per day. Young males with IGD showed an altered FC pattern in the dorsal striatum during follow\u2010up. FC of the dorsal striatum in IGD increased in the mPFC and decreased in the MOG. These findings showed that IGD was accompanied by weakening of prefrontal control and strengthening of the sensorimotor network, suggesting that uncontrolled gaming may be related with functional neural changes in the dorsal striatum.<\/jats:p>","DOI":"10.1111\/adb.12868","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T11:58:57Z","timestamp":1577707137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dorsal striatal functional connectivity changes in Internet gaming disorder: A longitudinal magnetic resonance imaging study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5425-4677","authenticated-orcid":false,"given":"Deokjong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yongin Severance Hospital Yonsei University College of Medicine Yongin South Korea"},{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee","family":"Namkoong","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Psychiatry, Severance Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghan","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Psychiatry, Severance Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-2510","authenticated-orcid":false,"given":"Young\u2010Chul","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Psychiatry, Severance Hospital Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-011-9318-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12162"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chb.2010.07.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci2030347"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12570"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00252"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1579"},{"key":"e_1_2_8_9_1","volume-title":"The role of executive control in human drug addiction. 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