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Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 \u00b1 5 years of age). Eighteen healthy volunteers (HVs) and fourteen CUs underwent a positron emission tomography scan using the FAAH radioligand [<jats:sup>11<\/jats:sup>C]CURB. Regional [<jats:sup>11<\/jats:sup>C]CURB binding was calculated using an irreversible two\u2010tissue compartment model with a metabolite\u2010corrected arterial plasma input function. The FAAH C385A genetic polymorphism (rs324420) was included as a covariate. All CUs underwent a urine screen to confirm recent cannabis use and had serum cannabinoids measured. One CU screened negative for cannabinoids via serum and was removed from analysis. All HVs reported less than five lifetime cannabis exposures more than a month prior to study initiation. There was a significant effect of group (<jats:italic>F<\/jats:italic><jats:sub>1,26<\/jats:sub> = 4.31; <jats:italic>P<\/jats:italic> = .048) when two A\/A (rs324420) HVs were removed from analysis to match the genotype of the CU group (n = 16 HVs, n = 13 CUs). Overall, [<jats:sup>11<\/jats:sup>C]CURB <jats:italic>\u03bbk<\/jats:italic><jats:sub>3<\/jats:sub> was 12% lower in CU compared with HV. Exploratory correlations showed that lower brain [<jats:sup>11<\/jats:sup>C]CURB binding was related to greater use of cannabis throughout the past year. We confirmed our previous report and extended these findings by detecting lower [<jats:sup>11<\/jats:sup>C]CURB binding in a younger cohort with less cumulative cannabis exposure.<\/jats:p>","DOI":"10.1111\/adb.12872","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T05:14:33Z","timestamp":1579583673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Fatty acid amide hydrolase is lower in young cannabis users"],"prefix":"10.1111","volume":"26","author":[{"given":"Maya R.","family":"Jacobson","sequence":"first","affiliation":[{"name":"Research Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-2053","authenticated-orcid":false,"given":"Rachel F.","family":"Tyndale","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Rusjan","sequence":"additional","affiliation":[{"name":"Research Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Boileau","sequence":"additional","affiliation":[{"name":"Research Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-7928","authenticated-orcid":false,"given":"Romina","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Research Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for 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