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The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug\u2010seeking and drug\u2010taking habits. Furthermore, these persistent drug\u2010related memories seemingly coexist with cognitive decline that predicts worse therapeutic output. Here, we use a new animal model of cocaine\u2010altered cognition that allowed to observe these events in the same individual and study their relationship. Mice were chronically administered cocaine in a conditioned place preference (CPP) apparatus for 14 days, and control mice received saline. After 28 days of cocaine withdrawal, animals were tested for retrieval of remote drug\u2013associated memory as well as for cognitive performance in a battery of tests, including novel object and place recognition and spatial memory. The cocaine\u2010withdrawn mice showed persistent CPP memory while impaired in the cognitive tasks, displaying deficits in reference memory acquisition and working memory. However, the CPP expression was not associated with the defective cognitive performance, indicating that they were concomitant but independent occurrences. After completion of the experiment, adult hippocampal neurogenesis (AHN) was studied as a relevant neurobiological correlate due to its potential role in both learning and drug addiction. Results suggested a preserved basal AHN in the cocaine\u2010withdrawn mice but an aberrant learning\u2010induced regulation of these neurons. This paradigm may be useful to investigate maladaptive cognition in drug addiction as well as related therapies.<\/jats:p>","DOI":"10.1111\/adb.12886","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T06:56:48Z","timestamp":1582527408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine\u2010altered cognition"],"prefix":"10.1111","volume":"26","author":[{"given":"M. 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