{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:22:47Z","timestamp":1793200967582,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA026861"],"award-info":[{"award-number":["DA026861"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA040369"],"award-info":[{"award-number":["DA040369"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA048125"],"award-info":[{"award-number":["DA048125"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K99 DA048125 to E.A.W."],"award-info":[{"award-number":["K99 DA048125 to E.A.W."]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["NIH grants F31 DA040369"],"award-info":[{"award-number":["NIH grants F31 DA040369"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["NIH grant R01 DA026861 to M.K.G."],"award-info":[{"award-number":["NIH grant R01 DA026861 to M.K.G."]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine\u2010 and cue\u2010primed reinstatement of cocaine\u2010seeking behavior in preclinical studies. In this inpatient study, the effects of NAC maintenance versus placebo on cocaine\u2010seeking behavior were examined during cocaine\u2010primed and unprimed self\u2010administration sessions among non\u2010treatment\u2010seeking, cocaine\u2010dependent individuals. Twelve participants completed this double\u2010blind, placebo\u2010controlled, within\u2010subject crossover study. Each participant was maintained for 1 week (Sat\u2013Fri) on NAC (1200\u2010mg TID; 3600 mg\/day total) and 1 week on placebo (0\u2010mg TID); medication order was randomized. A subset of participants underwent proton magnetic resonance spectroscopy scans (\n                    <jats:italic>n<\/jats:italic>\n                    = 8) on the third day of medication (Mon) to assess neurochemistry in the rostral anterior cingulate (rACC; voxel = 4.5 cm\n                    <jats:sup>3<\/jats:sup>\n                    ). In four randomized sessions (Tue\u2013Fri) each week, each participant could earn unit amounts of cocaine (10 mg, fixed) versus money ($0.50 vs. $1.50) on a choice, progressive ratio schedule after insufflating active versus placebo cocaine\u2010priming doses (110 mg vs. 4 mg). Relative to the placebo priming dose, the active cocaine priming dose (110 mg) increased cocaine\u2010seeking behavior (\n                    <jats:italic>p<\/jats:italic>\n                    = .003). NAC reduced cocaine\u2010primed cocaine\u2010seeking behavior compared with placebo levels (\n                    <jats:italic>p<\/jats:italic>\n                    = .044) but did not alter placebo\u2010primed cocaine\u2010seeking behavior. The larger money alternative ($1.50) suppressed cocaine\u2010seeking behavior relative to the smaller money alternative ($0.50;\n                    <jats:italic>p<\/jats:italic>\n                    = .011). Compared with placebo levels, NAC significantly decreased rACC glutamate + glutamine levels (\n                    <jats:italic>p<\/jats:italic>\n                    = .035) and numerically decreased rACC glutamate levels (\n                    <jats:italic>p<\/jats:italic>\n                    = .085). These preliminary findings indicate that NAC suppresses cocaine\u2010seeking behavior in some, but not all, experimental scenarios. Further, our findings suggest NAC may exert its therapeutic effects by modulating excitatory tone in the rACC.\n                  <\/jats:p>","DOI":"10.1111\/adb.12900","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T20:15:05Z","timestamp":1585080905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["<i>N<\/i>\n                    \u2010acetylcysteine reduces cocaine\u2010seeking behavior and anterior cingulate glutamate\/glutamine levels among cocaine\u2010dependent individuals"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-7260","authenticated-orcid":false,"given":"Eric A.","family":"Woodcock","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie H.","family":"Lundahl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalal","family":"Khatib","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-7321","authenticated-orcid":false,"given":"Mark K.","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00214-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-j0006.2000"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2515"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05144.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1069"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12127"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1007-05.2005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.11.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.226"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.179317"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.12.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.09.019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.10.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490500419169"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1115"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2013.12034.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.05.039"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.66"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.03.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950070060011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.9.1218"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01581.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.175"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301568"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.2833"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.05.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.07.016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2019.03.011"},{"key":"e_1_2_9_32_1","volume-title":"Structured Clinical Interview for DSM\u2010IVAxis I Disorders* Research Version, SCID\u2010I, Version 2.0","author":"First M","year":"1996"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.04.028"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(93)90042-O"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00164-1"},{"key":"e_1_2_9_36_1","unstructured":"ProvencherS.LCModel. Version 6.3.2008."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340105"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1655-z"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(90)90013-7"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.93"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.11.1789"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2012.04.006"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.150"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T10:12:23Z","timestamp":1693649543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/adb.12900"],"URL":"https:\/\/doi.org\/10.1111\/adb.12900","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]},"assertion":[{"value":"2019-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12900"}}