{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:55Z","timestamp":1753878415685,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA037317\u201002S2"],"award-info":[{"award-number":["DA037317\u201002S2"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Overdose of stimulant drugs has been associated with increased risk of adverse cardiovascular events (ACVE), some of which may be ascribed to endothelial dysfunction. The aims of this study were to evaluate biomarkers of endothelial dysfunction in emergency department (ED) patients with acute cocaine overdose and to assess the association between in\u2010hospital ACVE in ED patients with any acute drug overdose. This was a prospective consecutive cohort study over 9 months (2015\u20132016) at two urban, tertiary\u2010care hospital EDs. Consecutive adults (\u226518 years) presenting with suspected acute drug overdose were eligible and separated into three groups: cocaine (<jats:italic>n<\/jats:italic> = 47), other drugs (<jats:italic>n<\/jats:italic> = 128), and controls (<jats:italic>n<\/jats:italic> = 11). Data were obtained from medical records and linked to waste serum specimens, sent as part of routine clinical care, for biomarker analysis. Serum specimens were collected and analyzed using enzyme\u2010linked immunosorbent assay kit for three biomarkers of endothelial dysfunction: (a) endothelin\u20101 (ET\u20101), (b) regulated upon activation normal T cell expressed and secreted (RANTES), and (c) soluble intercellular adhesion molecule\u20101 (siCAM\u20101). Mean siCAM was elevated for cocaine compared with controls and other drugs (<jats:italic>p<\/jats:italic> &lt; .01); however, mean RANTES and ET\u20101 levels were not significantly different for any drug exposure groups. Receiver operating characteristics curve analysis for prediction of in\u2010hospital ACVE revealed excellent performance of siCAM\u20101 (area under curve, 0.86; <jats:italic>p<\/jats:italic> &lt; .001) but lack of predictive utility for either RANTES or ET\u20101. These results suggest that serum siCAM\u20101 is a viable biomarker for acute cocaine overdose and that endothelial dysfunction may be an important surrogate for adverse cardiovascular events following any drug overdose.<\/jats:p>","DOI":"10.1111\/adb.12901","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T13:51:50Z","timestamp":1586958710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biomarkers of endothelial dysfunction in cocaine overdose and overdose\u2010related cardiovascular events"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-9320","authenticated-orcid":false,"given":"Alex F.","family":"Manini","sequence":"first","affiliation":[{"name":"Division of Medical Toxicology, Department of Emergency Medicine The Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire L.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neuroscience, and Pharmacological Sciences The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-5706","authenticated-orcid":false,"given":"Michael L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neuroscience, and Pharmacological Sciences The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne D.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen C.","family":"Vargas\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Vedanthan","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Langone School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin L.","family":"Hurd","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neuroscience, and Pharmacological Sciences The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13358"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2012.01397.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.04.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-008-9025-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360544"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000140"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.11.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0969"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/9.6.241"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12658"}],"container-title":["Addiction 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