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The present study used seed\u2010based <jats:italic>d<\/jats:italic> mapping (SDM) to determine the extent to which a systematic difference in the WM integrity of cocaine users may exist (as compared with that of healthy controls). Articles from 2006 (when TBSS was first developed) to present were reviewed, with eight selected for inclusion. Meta\u2010analysis found lower fractional anisotropy (FA) in the genu of the corpus callosum for cocaine users, with a small\u2010to\u2010moderate peak effect size (Hedge's <jats:italic>g<\/jats:italic> = \u22120.331). Sensitivity analyses mostly supported the robustness of the obtained difference. Differences detected at exploratory thresholds for significance suggested insult to WM integrity extending beyond the corpus callosum. The present results compliment a previous region\u2010of\u2010interest (ROI)\u2010based meta\u2010analysis of DTI studies in individuals with CUD. These findings have significant implications for the potential role of neuroprotective agents in the treatment of CUD and merit additional iteration as more studies accrue in the literature.<\/jats:p>","DOI":"10.1111\/adb.12902","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T09:26:50Z","timestamp":1586338010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A meta\u2010analysis of tract\u2010based spatial statistics studies examining white matter integrity in cocaine use disorder"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-3754","authenticated-orcid":false,"given":"Robert","family":"Suchting","sequence":"first","affiliation":[{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-3286","authenticated-orcid":false,"given":"Charlotte L.","family":"Beard","sequence":"additional","affiliation":[{"name":"Department of Psychology Palo Alto University  Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-4614","authenticated-orcid":false,"given":"Joy M.","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-3095","authenticated-orcid":false,"given":"Heather E.","family":"Soder","sequence":"additional","affiliation":[{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-8977","authenticated-orcid":false,"given":"Jin H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khader M.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-4346","authenticated-orcid":false,"given":"Ponnada A.","family":"Narayana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-6539","authenticated-orcid":false,"given":"Scott D.","family":"Lane","sequence":"additional","affiliation":[{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Center for Behavioral Health Statistics and Quality.2017National Survey on Drug Use and Health. 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