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We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3\u2010year, annually acquired, longitudinal resting\u2010state functional magnetic resonance imaging (MRI) data of 526 adolescents (12\u201321 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) cohort, developmental trajectories of 23 intrinsic functional networks (IFNs) were analyzed for (1) sexual dimorphism in 259 participants who were no\u2010to\u2010low drinkers throughout this period; (2) sex\u2010alcohol interactions in two age\u2010 and sex\u2010matched NCANDA subgroups (<jats:italic>N<\/jats:italic> = 76 each), half no\u2010to\u2010low, and half moderate\u2010to\u2010heavy drinkers; and (3) moderating effects of gender\u2010specific alcohol dose effects and a multifactorial impulsivity measure on IFN connectivity in all NCANDA participants. Results showed that sex differences in no\u2010to\u2010low drinkers diminished with age in the inferior\u2010occipital network, yet girls had weaker within\u2010network connectivity than boys in six other networks. Effects of adolescent alcohol use were more pronounced in girls than boys in three IFNs. In particular, girls showed greater within\u2010network connectivity in two motor networks with more alcohol consumption, and these effects were mediated by sensation\u2010seeking only in girls. Our results implied that drinking might attenuate the naturally diminishing sexual differences by disrupting the maturation of network efficiency more severely in girls. The sex\u2010alcohol\u2010dose effect might explain why women are at higher risk of alcohol\u2010related health and psychosocial consequences than men.<\/jats:p>","DOI":"10.1111\/adb.12914","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T22:24:00Z","timestamp":1589927040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-0889","authenticated-orcid":false,"given":"Qingyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-3716","authenticated-orcid":false,"given":"Edith 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