{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:20:39Z","timestamp":1791462039785,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2017\u2010022"],"award-info":[{"award-number":["2017\u2010022"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2017\u2010022"],"award-info":[{"award-number":["2017\u2010022"]}],"id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001739","name":"National Institute for Psychobiology in Israel, Hebrew University of Jerusalem","doi-asserted-by":"publisher","award":["207\u201018\u201019"],"award-info":[{"award-number":["207\u201018\u201019"]}],"id":[{"id":"10.13039\/501100001739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1916\u201013"],"award-info":[{"award-number":["1916\u201013"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["968\u201013"],"award-info":[{"award-number":["968\u201013"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Relapse to alcohol abuse is often caused by exposure to potent alcohol\u2010associated cues. Therefore, disruption of the cue\u2010alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval and then restabilize within 6 h during a \u201creconsolidation\u201d process. We recently showed that relapse to cocaine seeking in a place\u2010conditioning paradigm could be prevented by counterconditioning the cocaine cues with aversive outcomes following cocaine\u2010memory retrieval. However, to better model addiction\u2010related behaviors, self\u2010administration models are necessary. Here, we demonstrate that relapse to alcohol seeking can be prevented by aversive counterconditioning conducted during alcohol\u2010memory reconsolidation, in the place conditioning and operant self\u2010administration paradigms, in mice and rats, respectively. We found that the reinstatement of alcohol\u2010conditioned place preference was abolished only when aversive counterconditioning with water flooding was given shortly after alcohol\u2010memory retrieval. Furthermore, rats trained to lever press for alcohol showed decreased context\u2010induced renewal of alcohol\u2010seeking responding when the lever pressing was punished with foot\u2010shocks, shortly, but not 6 h, after memory retrieval. These results suggest that aversive counterconditioning can prevent relapse to alcohol seeking only when performed during alcohol\u2010memory reconsolidation, presumably by updating, or replacing, the alcohol memory with aversive information. Finally, we found that aversive counterconditioning preceded by alcohol\u2010memory retrieval was characterized by the upregulation of brain\u2010derived neurotrophic factor (\n                    <jats:italic>Bdnf<\/jats:italic>\n                    ) mRNA expression in the medial prefrontal cortex, suggesting that BDNF may play a role in the memory updating process.\n                  <\/jats:p>","DOI":"10.1111\/adb.12935","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T05:44:21Z","timestamp":1594619061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-8599","authenticated-orcid":false,"given":"Koral","family":"Goltseker","sequence":"first","affiliation":[{"name":"School of Psychological Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hen","family":"Handrus","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-6777","authenticated-orcid":false,"given":"Segev","family":"Barak","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"School of Psychological Sciences, Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-011-0224-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4027-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0019463"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.49.3.360"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0030593"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00182"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03197954"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03198938"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"Reducing negative stimulus valence does not attenuate the return of fear: two counterconditioning experiments","volume":"120","author":"Dis EAM","year":"2019","journal-title":"Behav Res Ther"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.04.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.022"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3439"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0009-15.2015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215070"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9301"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.140"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.132"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2012.12.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45492-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13323"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2018.05.014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.08.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033457"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095760"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.02.018"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.08.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1559-y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005554107"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25568-5"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2127-x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2014.01.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12152"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0890-17.2017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2007.00070.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07277.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0090"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(79)90057-2"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.01.009"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.07.007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.10.002"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00242"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.035543.114"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00084-0"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0249-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0023146"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.029520.112"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1186909"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.03.019"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/75698"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fadb.12935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.12935","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.12935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:01:54Z","timestamp":1693598514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.12935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/adb.12935"],"URL":"https:\/\/doi.org\/10.1111\/adb.12935","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/841536","asserted-by":"object"}]},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]},"assertion":[{"value":"2020-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12935"}}