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Despite high rates of cigarette and cannabis co\u2010use, its role in cannabis cue reactivity remains unclear. Using a visual functional magnetic resonance imaging cue reactivity paradigm, we investigated interactive effects of cannabis and cigarette use on cannabis cue relative to cigarette and neutral cue reactivity in a priori regions of interest\u2014the amygdala, striatum, anterior cingulate cortex (ACC), ventral tegmental area (VTA), and orbitofrontal cortex\u2014and a whole\u2010brain analysis. In our sample of cannabis users and controls closely matched on cigarette use, significant interactions between cannabis and cigarette use status emerged in the amygdala, striatum, ACC, frontal pole, and inferior frontal gyrus. Cannabis\u2010only users showed heightened cue reactivity in the amygdala compared with nonusing controls. Co\u2010users did not show heightened cue reactivity compared with cigarette smoking controls, although cue\u2010induced VTA activity was positively correlated with grams per week of cannabis. Cigarette smoking controls showed unexpectedly heightened cue reactivity compared to co\u2010users and nonsmoking controls. These findings and the high prevalence of cannabis and cigarette co\u2010use underscore the importance of considering cigarette smoking status when investigating the role of cue reactivity in heavy cannabis use.<\/jats:p>","DOI":"10.1111\/adb.12941","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T05:00:59Z","timestamp":1596690059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Unraveling the role of cigarette use in neural cannabis cue reactivity in heavy cannabis users"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-8905","authenticated-orcid":false,"given":"Lauren","family":"Kuhns","sequence":"first","affiliation":[{"name":"Neuroscience of Addiction (NofA) Lab, Department of Psychology University of Amsterdam  Amsterdam The Netherlands"},{"name":"The Amsterdam Brain and Cognition Center (ABC) University of Amsterdam  Amsterdam 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