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However, it is unknown whether similar or different vmPFC neuronal ensembles mediate food and cocaine seeking. Here, we used the Daun02 inactivation procedure to assess whether the neuronal ensembles mediating food and cocaine seeking can be functionally distinguished. We trained male and female Fos\u2010LacZ rats to self\u2010administer palatable food pellets and cocaine on alternating days for 18 days. We then exposed the rats to a brief nonreinforced food\u2010 or cocaine\u2010seeking test to induce Fos and \u03b2\u2010gal in neuronal ensembles associated with food or cocaine seeking, respectively and infused Daun02 into vmPFC to ablate the \u03b2\u2010gal\u2010expressing ensembles. Two days later, we tested the rats for food or cocaine seeking under extinction conditions. Although inactivation of the food\u2010seeking ensemble did not influence food or cocaine seeking, inactivation of the cocaine\u2010seeking ensemble reduced cocaine seeking but not food seeking. Results indicate that the neuronal ensemble activated by cocaine seeking in vmPFC is functionally separate from the ensemble activated by food seeking.<\/jats:p>","DOI":"10.1111\/adb.12943","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T22:54:20Z","timestamp":1595199260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Fos\u2010expressing neuronal ensemble in rat ventromedial prefrontal cortex encodes cocaine seeking but not food seeking in rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Louisa","family":"Kane","sequence":"first","affiliation":[{"name":"Behavioral Neuroscience Branch IRP\/NIDA\/NIH\/DHHS  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-957X","authenticated-orcid":false,"given":"Marco","family":"Venniro","sequence":"additional","affiliation":[{"name":"Behavioral Neuroscience Branch IRP\/NIDA\/NIH\/DHHS  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-4683","authenticated-orcid":false,"given":"Richard","family":"Quintana\u2010Feliciano","sequence":"additional","affiliation":[{"name":"Behavioral Neuroscience Branch IRP\/NIDA\/NIH\/DHHS  Baltimore Maryland USA"},{"name":"Department of Pharmacodynamics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-302X","authenticated-orcid":false,"given":"Rajtarun","family":"Madangopal","sequence":"additional","affiliation":[{"name":"Behavioral Neuroscience Branch IRP\/NIDA\/NIH\/DHHS  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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