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It is especially unclear whether neural alterations related to PIT are due to the physiological effects of substance abuse or rather related to learning processes and\/or other etiological factors related to addiction. We have thus investigated whether neural activation patterns during a PIT task help to distinguish subjects with gambling disorder (GD), a nonsubstance\u2010based addiction, from healthy controls (HCs). Thirty GD and 30 HC subjects completed an affective decision\u2010making task in a functional magnetic resonance imaging (fMRI) scanner. Gambling\u2010associated and other emotional cues were shown in the background during the task. Data collection and feature modeling focused on a network of nucleus accumbens (NAcc), amygdala, and orbitofrontal cortex (OFC) (derived from PIT and substance use disorder [SUD] studies). We built and tested a linear classifier based on these multivariate neural PIT signatures. GD subjects showed stronger PIT than HC subjects. Classification based on neural PIT signatures yielded a significant area under the receiver operating curve (AUC\u2010ROC) (0.70,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013). GD subjects showed stronger PIT\u2010related functional connectivity between NAcc and amygdala elicited by gambling cues, as well as between amygdala and OFC elicited by negative and positive cues. HC and GD subjects were thus distinguishable by PIT\u2010related neural signatures including amygdala\u2013NAcc\u2013OFC functional connectivity. Neural PIT alterations in addictive disorders might not depend on the physiological effect of a substance of abuse but on related learning processes or even innate neural traits.\n                  <\/jats:p>","DOI":"10.1111\/adb.12951","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T17:19:18Z","timestamp":1596647958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neural correlates of cue\u2010induced changes in decision\u2010making distinguish subjects with gambling disorder from healthy controls"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-0709","authenticated-orcid":false,"given":"Alexander","family":"Genauck","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Bernstein Center for Computational Neuroscience Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Matthis","sequence":"additional","affiliation":[{"name":"Bernstein Center for Computational Neuroscience Berlin  Berlin Germany"},{"name":"Institute of Software Engineering and Theoretical Computer Science, Neural Information Processing Technische Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Andrejevic","sequence":"additional","affiliation":[{"name":"Melbourne School of Psychological Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Ballon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Chiarello","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Duecker","sequence":"additional","affiliation":[{"name":"Department of Psychology Carl\u2010von\u2010Ossietzky Universit\u00e4t Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kathmann","sequence":"additional","affiliation":[{"name":"Department of Psychology Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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