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These compounds have been related to several intoxication cases, including fatalities. Although the pharmacological effects, metabolism, and pharmacokinetics of cathinones have been studied, there is little information about the permeability of these compounds through the blood\u2013brain barrier (BBB). This is an important parameter to understand the behavior and potency of cathinones. In this work, 13 selected cathinones have been analyzed in telencephalon tissue from Sprague\u2013Dawley rats intraperitoneally dosed at 3 mg\/kg. Our results revealed a direct relationship between compound polarity and BBB permeability, with higher permeability for the more polar cathinones. The chemical moieties present in the cathinone had an important impact on the BBB permeability, with lengthening of the \u03b1\u2010alkyl chain or functionalization of the aromatic ring with alkyl moieties resulting in lower concentration in telencephalon tissue. Our data suggest that transport of cathinones is a carrier\u2010mediated process, similar to cocaine transport across the BBB.<\/jats:p>","DOI":"10.1111\/adb.12979","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T01:08:50Z","timestamp":1606957730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Understanding the pharmacokinetics of synthetic cathinones: Evaluation of the blood\u2013brain barrier permeability of 13 related compounds in rats"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-227X","authenticated-orcid":false,"given":"David","family":"Fabregat\u2010Safont","sequence":"first","affiliation":[{"name":"Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water Jaume I University  Castell\u00f3n 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