{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:08Z","timestamp":1787013788531,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["N01DA\u201018\u20108936"],"award-info":[{"award-number":["N01DA\u201018\u20108936"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylhexedrone, 4\u2010chloroethcathinone (4\u2010CEC), and 4\u2032\u2010methyl\u2010\u03b1\u2010pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant\u2010like effects to assess their abuse liability. Locomotor activity was assessed in an open\u2010field assay using Swiss\u2013Webster mice to screen for locomotor stimulant effects and to identify behaviorally\u2010active dose ranges, times of peak effect, and durations of action. Discriminative stimulus effects were assessed in separate groups of Sprague\u2013Dawley rats trained to discriminate cocaine or methamphetamine from vehicle. Dipentylone,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylhexedrone, 4\u2010CEC, and MPHP dose\u2010dependently increased locomotor activity. Dipentylone,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylhexedrone, and MPHP produced maximal stimulant effects similar to cocaine and methamphetamine. 4\u2010CEC was less efficacious, producing peak stimulant effects of about 74% of that of methamphetamine. The compounds were less potent than methamphetamine and approximately equipotent with cocaine. The doses of cocaine, methamphetamine, dipentylone, and 4\u2010CEC that produced peak effects lasted 2 to 3\u00a0h, the peak dose of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylhexedrone lasted 4\u00a0h, and the peak dose of MPHP lasted 6\u00a0h. All four compounds fully substituted for the discriminative stimulus effects of methamphetamine and cocaine, although full substitution by 4\u2010CEC occurred at doses that substantially decreased response rate. Only 4\u2010CEC fully substituted for MDMA. These data provide evidence that the novel cathinone compounds dipentylone,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylhexedrone, 4\u2010CEC, and MPHP demonstrate potential for abuse as psychostimulants, given their ability to stimulate locomotor activity and their substitution for the discriminative stimulus effects of methamphetamine and cocaine.\n                  <\/jats:p>","DOI":"10.1111\/adb.12987","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:52:29Z","timestamp":1604623949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Behavioral effects of four novel synthetic cathinone analogs in rodents"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-211X","authenticated-orcid":false,"given":"Michael B.","family":"Gatch","sequence":"first","affiliation":[{"name":"Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu A.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Sumien","sequence":"additional","affiliation":[{"name":"Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Forster","sequence":"additional","affiliation":[{"name":"Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"European Drug Report 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