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It is crucial to provide markers that could help to better identify people experiencing sports betting\u2010related harms. The current study investigated whether problem gambling status, sports betting passion, and trait\u2010self\u2010control modulate brain reactivity to sports betting cues. Sixty\u2010five frequent sports bettors (35 \u201cnonproblem bettors\u201d and 30 \u201cproblem bettors\u201d) were exposed to cues representing real upcoming sport events (with varying levels of winning confidence) that were made available or blocked for betting, during functional magnetic resonance imaging (fMRI) recording. Sports betting passion and trait\u2010self\u2010control were assessed using self\u2010report scales. Sport events nonavailable for betting elicited higher insular and striatal activation in problem bettors, as compared with nonproblem bettors. Within a large cluster encompassing the ventral striatum, hippocampus, and amygdala, lower trait\u2010self\u2010control was associated with increased brain reactivity to sport events with high levels of winning confidence that were nonavailable for betting. No significant effect of sports betting passion was observed. These findings suggest that sports bettors' brain reactivity to gambling unavailability might be a relevant marker of sports betting\u2010related harms, as well as of blunted trait\u2010self\u2010control.<\/jats:p>","DOI":"10.1111\/adb.12996","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T06:31:06Z","timestamp":1607063466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased brain reactivity to gambling unavailability as a marker of problem gambling"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-0898","authenticated-orcid":false,"given":"Damien","family":"Brevers","sequence":"first","affiliation":[{"name":"Institute for Health and Behaviour, Department of Behavioural and Cognitive Sciences University of Luxembourg  Esch\u2010sur\u2010Alzette 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