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However, the development and application of translational models of these preclinical approaches are at an incipient stage. The goal of this study was to examine how intravenous free\u2010access and progressive\u2010ratio, operant\u2010response human alcohol self\u2010administration paradigms can be used as translational human model parallels of preclinical \u201cliking\u201d and \u201cwanting.\u201d Participants were 40 adults (mean age\u00a0=\u00a023.7, SD\u00a0=\u00a02.0; 45% female) of European descent who reported 12.6 drinking days (SD\u00a0=\u00a05.2) out of the previous 30 (average\u00a0=\u00a04.1 drinks per drinking day [SD\u00a0=\u00a01.7]). Individuals diverged in their alcohol self\u2010administration behavior, such that free\u2010access and progressive\u2010ratio paradigm outcomes were not significantly correlated (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.44). Free\u2010access alcohol seeking was related to enjoying alcohol (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), but not craving (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.48), whereas progressive\u2010ratio seeking at similar levels of alcohol exposure was related to craving (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), but not enjoying (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.30). Family history of alcoholism, venturesomeness traits, and disinhibition traits were unrelated (<jats:italic>p<\/jats:italic>s\u00a0&gt;\u00a00.70) to preferred level of breath alcohol concentration (BrAC) in the free\u2010access session, a measure of liking alcohol. Family history of alcoholism, disinhibition traits, and recent drinking history were significantly related (<jats:italic>p<\/jats:italic>s\u00a0&lt;\u00a00.05) to alcohol seeking in the progressive\u2010ratio paradigm, a measure of wanting alcohol. We conclude that intravenous alcohol self\u2010administration paradigms show promise in modeling behaviors that characterize and parallel alcohol \u201cliking\u201d and \u201cwanting\u201d in preclinical models. These paradigms provide a translational link between preclinical methods and clinical trials.<\/jats:p>","DOI":"10.1111\/adb.13016","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T04:10:50Z","timestamp":1612757450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self\u2010administration paradigms"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1990-8337","authenticated-orcid":false,"given":"Melissa A.","family":"Cyders","sequence":"first","affiliation":[{"name":"Department of Psychology Indiana University\u2014Purdue University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Plawecki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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