{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:17:19Z","timestamp":1791357439963,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A threefold increase in fatal cocaine overdoses during the past decade highlights the critical lack of medications for cocaine use disorders. The brain response to drug cues can predict future drug use; however, results have been mixed. We present preliminary evidence that a sustained response to repeated cocaine cues within a single task is a significant predictor of drug\u2010use outcomes. Seventy\u2010three cocaine inpatients were administered a passive\u2010viewing fMRI task, featuring 500\u00a0ms novel evocative (cocaine, sexual, aversive) and neutral comparator cues in the first half (Half1), which were then repeated in the second half (Half2). After the baseline scan, patients received eight outpatient treatment weeks with twice\u2010weekly drug screens. Drug\u2010use outcome groups were empirically defined based on cocaine\u2010positive or missing urines averaged across the outpatient phase: GOOD (&lt;40%), POOR (&gt;85%), and Intermediate (INT, between 40% and 85%) outcomes. Differences of response to initial (Half1) and repeated (Half2) cues in <jats:italic>a priori<\/jats:italic> (cue\u2010reactive) regions were tested between outcome groups (3 [Group]\u00a0\u00d7\u00a02 [Halves] ANOVA). An interaction was found in the brain response to drug (but not sex or aversive) cues, with a significant difference between the GOOD and POOR outcome groups in Half2, driven by a significant decrease in brain response by the GOOD outcome group and a sustained brain response by the POOR outcome group, to repeated cocaine cues. The brain response to repeated drug cues may be a useful predictor of future drug use, encouraging future intervention studies to restore a \u201chealthy\u201d (decreasing) response to the repeated presentation of drug cues.<\/jats:p>","DOI":"10.1111\/adb.13028","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:44:26Z","timestamp":1614343466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Sustained brain response to repeated drug cues is associated with poor drug\u2010use outcomes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-1654","authenticated-orcid":false,"given":"Paul S.","family":"Regier","sequence":"first","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Jagannathan","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-6292","authenticated-orcid":false,"given":"Reagan R.","family":"Wetherill","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Langleben","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gawyrsiak","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle M.","family":"Kampman","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rose","family":"Childress","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"NCHS Data Brief, no 356","author":"Hedegaard H","year":"2020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-011-0224-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.11"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001506"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301371"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010070"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3342-z"},{"issue":"6","key":"e_1_2_8_9_1","first-page":"22","article-title":"Emotional, physical and sexual abuse are associated with a heightened limbic response to cocaine cues","volume":"22","author":"Regier PS","year":"2016","journal-title":"Addict Biol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1544-06.2006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.05.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07590.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00371-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.12040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.762"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19070703"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12314"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.03.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0232-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2007.00075.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.034"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2026"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.02.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntt214"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12182"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.01.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.6466"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00682-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1224-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0090"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300851"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.04.008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096146"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw095"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.10.012"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2565-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.10.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4977-13.2014"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.08.018"},{"issue":"20","key":"e_1_2_8_41_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_42_1","first-page":"1","article-title":"International affective picture system (IAPS): instruction manual and affective ratings","author":"Lang PJ","year":"1997","journal-title":"Cent Res Psychophysiol Univ Fla"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00279"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.028"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20261"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.36"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.323"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.059"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07915.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00273.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17101147"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:51:56Z","timestamp":1693356716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/adb.13028"],"URL":"https:\/\/doi.org\/10.1111\/adb.13028","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"2020-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13028"}}