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Lorcaserin, a 5\u2010HT<jats:sub>2C<\/jats:sub> receptor agonist, attenuates drug self\u2010administration in animal models. We investigated the effects of lorcaserin on EtOH intake using the drinking\u2010in\u2010the\u2010dark (DID) procedure, an animal model of binge\u2010like drinking. We compared the effects of lorcaserin to those of the Food and Drug Administration (FDA)\u2010approved drug naltrexone and examined the effects of combining lorcaserin and naltrexone. To examine whether effects were specific for EtOH, we examined the effects of lorcaserin and naltrexone, administered alone and in combination, on saccharin intake. Adult male C57BL\/6J mice received EtOH access (20% v\/v) for 2\u00a0h in the home\u2010cage during the first 3\u00a0days of the DID procedure, beginning 3\u00a0h into the dark cycle. On day 4, mice were injected with lorcaserin, naltrexone, or a combination of lorcaserin and naltrexone prior to a 4\u2010h EtOH access. Intake was measured at 2 and 4\u00a0h. Lorcaserin reduced EtOH intake in a dose\u2010dependent fashion over the 2\u2010 and 4\u2010h measurement periods. Naltrexone also reduced EtOH intake when administered alone, with dose\u2010dependent effects being more pronounced over 2\u00a0h rather than the full 4\u2010h session. Combining lorcaserin and naltrexone reduced binge\u2010like EtOH drinking to a greater extent than either drug alone. A similar pattern of results was obtained for saccharin intake. These results suggest that lorcaserin and naltrexone can have additive effects on binge\u2010like EtOH drinking. They also support continued research into the therapeutic potential of lorcaserin for alcohol use disorders.<\/jats:p>","DOI":"10.1111\/adb.13040","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:35:40Z","timestamp":1619760940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge\u2010like ethanol drinking"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-6672","authenticated-orcid":false,"given":"Rayane I.","family":"Tabbara","sequence":"first","affiliation":[{"name":"Section of Biopsychology and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychology University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Biopsychology and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-2280","authenticated-orcid":false,"given":"Paul J.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Section of Biopsychology and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychology University of Toronto  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh D.","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"},{"name":"Neurobiology of Alcohol Laboratory and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)90630-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249132"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(82)90026-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb01373.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.85"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00024-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80195-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00047-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02246-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100801"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.303"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"1183","article-title":"Studies to investigate the role of 5\u2010HT2C receptors on cocaine\u2010 and food\u2010maintained behavior","volume":"295","author":"Grottick AJ","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.09.028"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00413"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.09.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00710-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.07.017"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.10.007"},{"key":"e_1_2_7_21_1","unstructured":"National Institute on Alcohol Abuse and Alcoholism Newsletter.National Institute on Alcohol Abuse and Alcoholism Council approves definition of binge drinking.https:\/\/pubs.niaaa.nih.gov\/publications\/Newsletter\/winter2004\/Newsletter_Number3.pdf. 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