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Longitudinal functional magnetic resonance imaging (fMRI) data from 22 IGD subjects and 18 healthy controls were collected at baseline and more than 6\u2009months later. We examined the connectivity features of subregions within the striatum between these two scans. Based on the results, we further performed dynamic causal modelling to explore the directional effect between regions and used these key features for data classification in machine learning to test the replicability of the results. Compared with controls, IGD subjects exhibited decreased functional connectivity between the left dorsal striatum (putamen) and the left insula, whereas connectivity between the right ventral striatum (nucleus accumbens [Nacc]) and the left insula was relatively stable over time. An inhibitory effective connectivity from the left putamen to the right Nacc was found in IGD subjects during the follow\u2010up scan. Using the above features, the classification accuracy of the training model developed with the follow\u2010up was better than that of the model based on the initial scan. Persistent IGD status was accompanied by a switch in the locus of control within the striatum, which provided new insights into association between IGD and drug addiction.<\/jats:p>","DOI":"10.1111\/adb.13046","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T12:12:23Z","timestamp":1620475943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Persistent dependent behaviour is accompanied by dynamic switching between the ventral and dorsal striatal connections in internet gaming disorder"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-1983","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal University Hangzhou 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