{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:38:21Z","timestamp":1785245901212,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA007273"],"award-info":[{"award-number":["T32 DA007273"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA DA047265"],"award-info":[{"award-number":["R01 DA DA047265"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R00 DA033372"],"award-info":[{"award-number":["R00 DA033372"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disruption of prefrontal glutamate receptor interacting protein (GRIP), which anchors GluA2\u2010containing AMPA receptors (AMPARs) into the synaptic membrane, potentiates cue\u2010induced cocaine seeking in both males and females. Protein interacting with C kinase 1 (PICK1) plays an opposing role to that of GRIP, removing AMPARs from the synapse. Consistent with our hypothesis that disruption of PICK1 in the mPFC would lead to a decrease in addiction\u2010like behaviour, we found that conditional deletion of PICK1 in the mPFC attenuates cue\u2010induced cocaine seeking in male mice. However, prefrontal PICK1 deletion had the opposite effect in females, leading to an increase in cue\u2010induced reinstatement of cocaine seeking. We did not see any effects of PICK1 knockdown on sucrose taking or seeking, suggesting the sex\u2010specific effects do not generalise to natural reinforcers. These findings suggest the role of PICK1 in the prefrontal cortex of females may not be consistent with its accepted role in males. To determine whether these sex differences were influenced by gonadal hormones, we gonadectomised a cohort of males and found that removal of circulating androgens eliminated the effect of prefrontal PICK1 knockdown. As there was no effect of gonadectomy on its own on any of the behavioural measures collected, our results suggest that androgens may be involved in compensatory downstream effects of PICK1 knockdown. Taken together, these results highlight the need for consideration of sex as a biological variable when examining mechanisms underlying all behaviours, as convergent sex differences can reveal different mechanisms where behavioural sex differences do not exist.<\/jats:p>","DOI":"10.1111\/adb.13051","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T23:13:00Z","timestamp":1623366780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sex\u2010specific role for prefrontal cortical protein interacting with C kinase 1 in cue\u2010induced cocaine seeking"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-1689","authenticated-orcid":false,"given":"Megan M.","family":"Wickens","sequence":"first","affiliation":[{"name":"Department of Psychology Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Kirkland","sequence":"additional","affiliation":[{"name":"Department of Psychology Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-4653","authenticated-orcid":false,"given":"Melissa C.","family":"Knouse","sequence":"additional","affiliation":[{"name":"Department of Psychology Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna G.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Psychology Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-5061","authenticated-orcid":false,"given":"Lisa A.","family":"Briand","sequence":"additional","affiliation":[{"name":"Department of Psychology Temple University  Philadelphia Pennsylvania USA"},{"name":"Neuroscience Program Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"e_1_2_10_2_1","series-title":"NSDUH Series H\u201053","volume-title":"Key Substance Use And Mental Health Indicators in the United States: Results From the 2017 National Survey on Drug Use and Health","author":"Administration SAaMHS","year":"2018"},{"key":"e_1_2_10_3_1","first-page":"23","volume-title":"International Narcotics Control Strategy Report Volume I: Drug and Chemical Control","author":"State USDo","year":"2019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12723"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.04.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.10.038"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02916.2002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.05.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.06.041"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01249"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350-11.2011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06995"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.07.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.08.011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.265"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.08.012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107672"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.66"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1196-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00725"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07134.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03452-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.03.011"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000488"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2007.07.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2080-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.10.007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0170-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098482"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00267-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0422-17.2018"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1149-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.2.4937"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.02.025"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00885-7"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.111.1.219"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.07.018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.09.025"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300387"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.06.054"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90256-V"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0845"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22768"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300656"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107901"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2054"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1221-08.2008"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1291-15.2016"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000636"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4802-7"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300778"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(99)00207-5"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.01.003"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.035"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.10.003"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2015.04.013"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.03.001"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:51:44Z","timestamp":1693356704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/adb.13051"],"URL":"https:\/\/doi.org\/10.1111\/adb.13051","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"assertion":[{"value":"2021-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13051"}}