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While previous studies have demonstrated that acupuncture modulates DA transmission in the mesolimbic reward system originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc) and can reduce drug self\u2010administration, the central links between peripheral acupuncture signals and brain reward systems are not well\u2010characterized. Thus, we hypothesised that acupuncture would elicit inhibitory signals from RMTg neurons to brain reward systems. Acupuncture reduced acute cocaine\u2010induced locomotor activity and DA release in a point\u2010specific manner, which was blocked by optogenetic silencing or chemical lesion of the RMTg. The acupuncture effect was mimicked by chemical activation of the RMTg. Acupuncture activated RMTg GABA neurons. In addition, the inhibitory effects of acupuncture on acute cocaine\u2010induced locomotor activity were prevented by electrolytic lesions of the lateral habenula (LHb) or fasciculus retroflexus (FR), areas known to project to the RMTg. These findings suggest that acupuncture recruits the RMTg to reduce the psychomotor responses enhanced by acute cocaine.<\/jats:p>","DOI":"10.1111\/adb.13052","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T04:21:49Z","timestamp":1620620509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acupuncture reduces cocaine psychomotor responses by activating the rostromedial tegmental nucleus"],"prefix":"10.1111","volume":"26","author":[{"given":"Suchan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"},{"name":"Department of Human Anatomy and Histoembryolgy Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonhee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Hyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center, College of Korean Medicine Daegu Haany University  Gyeongsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-3728","authenticated-orcid":false,"given":"Kyle B.","family":"Bills","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Noorda College of Osteopathic Medicine  Provo Utah USA"},{"name":"Department of Psychology and Neuroscience Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-8861","authenticated-orcid":false,"given":"Scott C.","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-1600","authenticated-orcid":false,"given":"Chae Ha","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-9115","authenticated-orcid":false,"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"issue":"17","key":"e_1_2_8_2_1","first-page":"1518","article-title":"NIH consensus conference. 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