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As DA receptors also dynamically regulate L\u2010type calcium channels (LTCCs), in this study we examined how DA receptors (D1R or D2R) and LTCCs (Ca<jats:sub>v<\/jats:sub>1.2 or Ca<jats:sub>v<\/jats:sub>1.3) exert their influences on cocaine\u2010seeking in a tree shrew (<jats:styled-content style=\"fixed-case\"><jats:italic>Tupaia belangeri chinensis<\/jats:italic><\/jats:styled-content>) model. First, we demonstrated the \u2018incubation\u2019 effect by showing tree shrews exhibited a significantly higher seeking behaviour on withdrawal day (WD) 45 than on WD1. Then, we confirmed that longer abstinence period induced higher D1R expression in the nucleus accumbens (NAc). Next, we showed that LTCCs in the NAc participated in drug seeking. Moreover, Ca<jats:sub>v<\/jats:sub>1.2 expression in the NAc was increased on WD45, and disruption of the Ca<jats:sub>v<\/jats:sub>1.2 inhibited drug seeking. Finally, we found that D1R antagonist blocked the increase of Ca<jats:sub>v<\/jats:sub>1.2 on drug\u2010seeking test. Collectively, these findings suggest that D1R\u2010mediated upregulation of Ca<jats:sub>v<\/jats:sub>1.2 is involved in the incubation of cocaine craving.<\/jats:p>","DOI":"10.1111\/adb.13053","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T06:46:50Z","timestamp":1620974810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor\u2010mediated upregulation of Ca<sub>v<\/sub>1.2"],"prefix":"10.1111","volume":"26","author":[{"given":"Ying","family":"Duan","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing 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