{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:37:21Z","timestamp":1768570641277,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Behavioural sensitization (BS) is characterized by enhanced psychomotor responses to a dose of substance of abuse after prior repeated exposure. We previously reported that BS can be induced by a single injection of morphine in rats, whereas septal nuclei are specifically involved in the development phase of BS. Here, we demonstrated that intra\u2010LS or intra\u2010MS microinjections also incubated BS to a systemic morphine injection in a cross\u2010sensitization fashion, whereas inactivation of either subdivision of septal nuclei (LS: lateral septum; MS: medial septum) can negate this ability of morphine. Then, non\u2010selective (naloxone) and selective (\u03bc\u2010, \u03b4\u2010 and \u03ba\u2010)opioid receptor antagonists were directly delivered into LS or MS, respectively, ahead of a morphine microinjection, whereas only \u03bc\u2010opioid receptors in both LS and MS play indispensable roles in mediating the BS development. Finally, there was a pronounced elevation in the levels of the monoamines (i.e. dopamine, homovanillic acid, 5\u2010hydroxytryptamine and 5\u2010hydroxyindoleacetic acid) in the septum, 8\u00a0h after a morphine injection detected with a HPLC\u2010ECD method, suggesting that dopaminergi and serotoninergic systems are implicated in the BS formation. Our studies demonstrated that septal nuclei critically participate in the BS development. Essentially, \u03bc\u2010 instead of \u03b4\u2010 or \u03ba\u2010opioid receptors in LS and MS mediate sensitization to opiates.<\/jats:p>","DOI":"10.1111\/adb.13066","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T23:14:11Z","timestamp":1621898051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mu\u2010opioid receptors in septum mediate the development of behavioural sensitization to a single morphine exposure in male rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Yu\u2010Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Peking University  Beijing China"},{"name":"Department of Pharmacy, East Hospital Tongji University School of Medicine  Shanghai 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