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This study demonstrated the linking of glutamate receptors in the nucleus accumbens (NAc) to vocal expression of 50\u2010kHz USV calls after repeated cocaine administration in freely moving rats. Repeated systemic injections of cocaine (20\u2009mg\/kg\/day, i.p.) for seven consecutive days increased the number of 50\u2010kHz USV calls. Intra\u2010NAc core infusion of the broad\u2010glutamate receptor antagonist, \u03b3DGG (50\u2009nmol\/side), decreased the repeated cocaine\u2010induced increase in the number of 50\u2010kHz USV calls. Intra\u2010NAc core infusion of the <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>D<\/jats:italic>\u2010aspartate (NMDA) receptor antagonist, MK801 (2\u00a0nmol\/side), but not \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazolepropionic acid or kainic acid receptor antagonist, CNQX disodium salt (2\u00a0nmol\/side), decreased the number of 50\u2010kHz USV calls that had been elevated by repeated exposure to cocaine. Intra\u2010NAc core infusion of the group I metabotropic glutamate receptor subtype 5 (mGluR5), MPEP (0.5\u00a0nmol\/side), MTEP (15\u2009nmol\/side) and inositol\u20101,4,5\u2010trisphosphate receptor blocker, xestospongin C (0.004\u2009nmol\/side) decreased the cocaine\u2010induced increase in the number of USV calls. These data suggest that the NMDA receptor\u2010 and mGluR5\u2010dependent increase in intracellular Ca<jats:sup>2+<\/jats:sup> concentrations in the NAc core is linked to a positive emotional state after repeated exposure to cocaine in rats.<\/jats:p>","DOI":"10.1111\/adb.13084","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T12:13:16Z","timestamp":1628683996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine\u2010induced 50\u2010kHz ultrasonic vocalization in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Sumin","family":"Sohn","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Pusan National University  Busan Republic of 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