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Studies in laboratory animals suggest that these effects are augmented by progressively greater drug use histories, impulsive personality traits, and acute drug ingestion. As a preliminary test of these hypotheses in humans, we exposed cocaine users (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914) and healthy volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) to cocaine\u2010related videos during two functional magnetic resonance imaging (fMRI) sessions, once following acute administration of placebo and once following\n                    <jats:italic>d<\/jats:italic>\n                    \u2010amphetamine (0.3\u2009mg\/kg, p.o.). Across sessions, cocaine users showed larger cocaine cue\u2010induced responses than healthy controls in the associative striatum and midbrain. Among the cocaine users, larger drug cue\u2010induced responses during the placebo session were correlated with higher Barratt Impulsiveness Scale (BIS\u201011) nonplanning scores (associative striatum) and greater lifetime use of stimulant drugs (limbic, associative, and sensorimotor striatum). The administration of\n                    <jats:italic>d<\/jats:italic>\n                    \u2010amphetamine did not augment the cue\u2010induced activations, but, in cocaine users, drug cue\u2010induced striatal activations were more widespread following prolonged cocaine cue exposure. Together, these effects of past and present drug use might aggravate the risk for stimulant drug use problems.\n                  <\/jats:p>","DOI":"10.1111\/adb.13094","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T06:57:25Z","timestamp":1630393045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cocaine cue\u2010induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-3081","authenticated-orcid":false,"given":"Val\u00e9rie","family":"D'Amour\u2010Horvat","sequence":"first","affiliation":[{"name":"Department of Psychology McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia M. 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