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Here, we exploited recent developments in graph\u2010theoretical analyses, enabling improved resolution and fine\u2010grained representation of brain networks, to investigate functional connectivity in 35 recently detoxified alcohol dependent patients versus 34 healthy controls. Specifically, we focused on the modular organization, that is, the presence of tightly connected substructures within a network, and on the identification of brain regions responsible for network integration using an unbiased approach based on a large\u2010scale network composed of more than 600 a priori defined nodes. We found significant reductions in global connectivity and region\u2010specific disruption in the network topology in patients compared with controls. Specifically, the basal brain and the insular\u2013supramarginal cortices, which form tightly coupled modules in healthy subjects, were fragmented in patients. Further, patients showed a strong increase in the centrality of the anterior insula, which exhibited stronger connectivity to distal cortical regions and weaker connectivity to the posterior insula. Anterior insula centrality, a measure of the integrative role of a region, was significantly associated with increased risk of relapse. Exploratory analysis suggests partial recovery of modular structure and insular connectivity in patients after 2\u2009weeks. These findings support the hypothesis that, at least during the early stages of abstinence, the anterior insula may drive exaggerated integration of interoceptive states in AUD patients with possible consequences for decision making and emotional states and that functional connectivity is dynamically changing during treatment.<\/jats:p>","DOI":"10.1111\/adb.13096","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T06:26:46Z","timestamp":1630477606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased network centrality of the anterior insula in early abstinence from alcohol"],"prefix":"10.1111","volume":"27","author":[{"given":"Cecile","family":"Bordier","sequence":"first","affiliation":[{"name":"Center for Neuroscience and Cognitive Systems Istituto Italiano di Tecnologia  Rovereto Italy"},{"name":"Univ. 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