{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:15:55Z","timestamp":1791807355637,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Methamphetamine (meth) causes enduring changes within the medial prefrontal cortex (mPFC) and the nucleus accumbens (NA). Projections from the mPFC to the NA have a distinct dorsal\u2010ventral distribution, with the prelimbic (PL) mPFC projecting to the NAcore, and the infralimbic (IL) mPFC projecting to the NAshell. Inhibition of these circuits has opposing effects on cocaine relapse. Inhibition of PL\u2010NAcore reduces cued reinstatement of cocaine seeking and IL\u2010NAshell inhibition reinstates cocaine seeking. Meth, however, exhibits a different profile, as pharmacological inhibition of either the PL or IL decrease cued reinstatement of meth\u2010seeking. The potentially opposing roles of the PL\u2010NAcore and IL\u2010NAshell projections remain to be explored in the context of cued meth seeking. Here we used an intersectional viral vector approach that employs a retrograde delivery of Cre from the NA and Cre\u2010dependent expression of DREADD in the mPFC, in both male and female rats to inhibit or activate these parallel pathways. Inhibition of the PL\u2010NAcore circuit reduced cued reinstatement of meth seeking under short and long\u2010access meth self\u2010administration and after withdrawal with and without extinction. Inhibition of the IL\u2010NAshell also decreased meth cued reinstatement. Activation of the parallel circuits was without an effect. These studies show that inhibition of the PL\u2010NAcore or the IL\u2010NAshell circuits can inhibit reinstated meth seeking. Thus, the neural circuitry mediating cued reinstatement of meth seeking is similar to cocaine in the dorsal, but not ventral, mPFC\u2010NA circuit.<\/jats:p>","DOI":"10.1111\/adb.13097","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T07:08:21Z","timestamp":1629875301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chemogenetic inhibition of corticostriatal circuits reduces cued reinstatement of methamphetamine seeking"],"prefix":"10.1111","volume":"27","author":[{"given":"Angela M.","family":"Kearns","sequence":"first","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-6054","authenticated-orcid":false,"given":"Benjamin M.","family":"Siemsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Scofield","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Anesthesiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Colorado Denver  Aurora Colorado USA"},{"name":"Department of Pharmacology University of Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-8754","authenticated-orcid":false,"given":"Carmela M.","family":"Reichel","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","first-page":"301","article-title":"The need for speed: an update on methamphetamine addiction","volume":"31","author":"Barr AM","year":"2006","journal-title":"J Psychiatry 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