{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:13:54Z","timestamp":1781511234248,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA048055"],"award-info":[{"award-number":["DA048055"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA049139"],"award-info":[{"award-number":["DA049139"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA034684"],"award-info":[{"award-number":["DA034684"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infralimbic cortical (IL) manipulations indicate that this region mediates extinction learning and suppresses cocaine seeking following cocaine self\u2010administration. However, little work has recorded IL activity <jats:italic>during the inhibition of cocaine seeking<\/jats:italic> due to the difficulty of determining precisely when cocaine\u2010seeking behaviour is inhibited within a cocaine\u2010seeking session. The present study used in vivo electrophysiology to examine IL activity across extinction as well as during cocaine self\u2010administration and reinstatement. Sprague\u2013Dawley rats underwent 6\u2010h access cocaine self\u2010administration in which the response lever was available during discrete signalled trials, a procedure which allowed for the comparison between epochs of cocaine seeking versus the inhibition thereof. Subsequently, rats underwent extinction and cocaine\u2010primed reinstatement using the same procedure. Results indicate that theta rhythms (4\u201310\u00a0Hz) dominated IL local\u2010field potential (LFP) activity during all experimental stages. During extinction, theta power fluctuated significantly surrounding the lever press and was lower when rats engaged in cocaine seeking versus when they withheld from doing so. These patterns of oscillatory activity differed from self\u2010administration and reinstatement stages. Single\u2010unit analyses indicate heterogeneity of IL unit responses, supporting the idea that multiple neuronal subpopulations exist within the IL and promote the expression of different and even opposing cocaine\u2010seeking behaviours. Together, these results are consistent with the idea that aggregate synaptic and single\u2010unit activity in the IL represent the engagement of the IL in action monitoring to promote adaptive behaviour in accordance with task contingencies and reveal critical insights into the relationship between IL activity and the inhibition of cocaine seeking.<\/jats:p>","DOI":"10.1111\/adb.13106","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T14:09:25Z","timestamp":1634825365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-2597","authenticated-orcid":false,"given":"Vict\u00f3ria A.","family":"M\u00fcller Ewald","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Iowa  Iowa City Iowa USA"},{"name":"Interdisciplinary Neuroscience Program University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program University of Iowa  Iowa City Iowa USA"},{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Farley","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program University of Iowa  Iowa City Iowa USA"},{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program University of Iowa  Iowa City Iowa USA"},{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"},{"name":"Iowa Neuroscience Institute University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"LaLumiere","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program University of Iowa  Iowa City Iowa USA"},{"name":"Department of Psychological and Brain Sciences University of Iowa  Iowa City Iowa USA"},{"name":"Iowa Neuroscience Institute University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2017.07.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.90"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2412-13.2013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4964-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0773-16.2016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-1034-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1576810"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3821-16.2017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12434"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.04.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.04.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(01)00278-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64962-w"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077707"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913016107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021714"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12578"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0918-19.2019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-07.2008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.021"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164781"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.401"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.4.926"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00093.2016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1965-17.2017"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00110"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.06.004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90351-H"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18533"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00765"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.049"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01147"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00080"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42409"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.10.030"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T15:19:37Z","timestamp":1711379977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/adb.13106"],"URL":"https:\/\/doi.org\/10.1111\/adb.13106","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"assertion":[{"value":"2021-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13106"}}