{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:51:38Z","timestamp":1785898298607,"version":"3.56.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671661"],"award-info":[{"award-number":["81671661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The abnormal interactions of three key large\u2010scale brain networks (default mode [DMN], salience and executive control [ECN]) were showed underlie dysfunctions in heroin addiction. Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a potential treatment for heroin addiction. It is unclear whether impaired coupling among the large\u2010scale brain networks would be improved by rTMS in treated heroin\u2010dependent individuals. Thirty\u2010five heroin\u2010dependent individuals were included in this sham\u2010controlled, randomized study. The patients received either active or sham rTMS for 1\u00a0week. The craving for heroin and resting\u2010state functional magnetic resonance imaging data were collected before and after 1\u2010week rTMS. Twenty\u2010two healthy subjects were included as controls not receiving rTMS. After 1\u2010week rTMS, only the active rTMS group showed a significant decrease in spontaneous and heroin cue\u2010induced craving. The coupling between left DLPFC (a key node of left ECN) and left parahippocampal gyrus (PHG, included in DMN) significantly increased for the active group with a tendency towards that of controls. The coupling between the right precentral gyrus and three key regions included in DMN (posterior cingulate cortex\/precuneus and bilateral inferior parietal cortex) significantly decreased for the active group with a tendency towards that of healthy controls. For the active rTMS individuals, the left DLPFC\u2010PHG coupling negatively correlated with the spontaneous craving and the drug cue\u2010induced craving. It suggested that the rTMS could reduce heroin craving, which might be related to the modulation of ECN\u2010DMN coupling. This finding might shed light on the mechanism of rTMS for heroin addiction treatment.<\/jats:p>","DOI":"10.1111\/adb.13121","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T05:55:26Z","timestamp":1638165326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Repetitive transcranial magnetic stimulation modulates coupling among large\u2010scale brain networks in heroin\u2010dependent individuals: A randomized resting\u2010state functional magnetic resonance imaging study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-9910","authenticated-orcid":false,"given":"Long","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianrong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-4083","authenticated-orcid":false,"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.10.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.4.395"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.09.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.357.6355.960"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.026"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106760"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.11.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.01.052"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.02.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102809"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S161206"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40473-017-0135-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12638"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/su11205725"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.48"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00208"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.01.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.02.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112562"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.11.018"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.11.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14753"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90777.2008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.4091"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311772110"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108177"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.04.010"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.06.024"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199001)46:1<35::AID-JCLP2270460106>3.0.CO;2-W"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.10.019"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2006.02.024"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12182"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00321-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.114"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.130306"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.048"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.06.009"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12674"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.026"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058098"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120861"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-145"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsx055"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0019"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1406-2"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00097-X"},{"issue":"18","key":"e_1_2_9_58_1","first-page":"1386","article-title":"Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users","volume":"7","author":"Hu W","year":"2012","journal-title":"Neural Regen Res"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016560"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m09965"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15181"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300851"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.10.026"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01757.x"},{"issue":"35","key":"e_1_2_9_65_1","first-page":"3344","article-title":"Brain areas activated by uncertain reward\u2010based decision\u2010making in healthy volunteers","volume":"8","author":"Guo Z","year":"2013","journal-title":"Neural Regen Res"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn140"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-019-00051-5"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.06.013"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T08:44:49Z","timestamp":1705913089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,28]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/adb.13121"],"URL":"https:\/\/doi.org\/10.1111\/adb.13121","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,28]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13121"}}