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The abnormal risk\u2010taking behaviour is an obvious feature of individuals with Internet gaming disorder (IGD). However, the relationship between the neural responses to missed chance and risk\u2010taking behaviour in IGD individuals remains unclear. In the current fMRI study, 28 IGD subjects (12 female, 23.04\u2009\u00b1\u20092.43\u2009years old) and 26 healthy control (HC) subjects (13 female, 23.58\u2009\u00b1\u20092.67\u2009years old) participated in fMRI scanning during performance of a sequential risk\u2010taking task. The general linear model and the psycho\u2010physiological interaction analyses were conducted to explore the difference in neural responses between the two groups. The results showed that IGD subjects reported more regret for the large missed chance and took more risk than HC subjects. Moreover, compared with HC subjects, IGD subjects exhibited greater activations in brain regions like ventral striatum (VS) and superior frontal gyrus (SFG), and stronger VS\u2010thalamus functional connectivity for the large missed chance. Additionally, among IGD subjects, the SFG activation for the large missed chance was positively correlated with the risk\u2010taking behaviour. Together, the results revealed the altered neural responses to missed chance contributed to the risk\u2010taking behaviour in IGD individuals. The findings could help to clearly understand why IGD individuals continue playing online games despite the risks of widely known and could provide a new perspective for the intervention of IGD.<\/jats:p>","DOI":"10.1111\/adb.13124","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T04:51:19Z","timestamp":1639198279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Altered neural responses to missed chance contribute to the risk\u2010taking behaviour in individuals with Internet gaming disorder"],"prefix":"10.1111","volume":"27","author":[{"given":"Zhiyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Behavior and Cognitive Neuroscience, School of Psychology Shaanxi Normal University  Xi'an 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