{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:28:03Z","timestamp":1780759683878,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2016\u20100100"],"award-info":[{"award-number":["FO2016\u20100100"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008052","name":"Fundaci\u00f3n Alfonso Mart\u00edn Escudero","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012103","name":"Stiftelsen Facias","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals with gambling disorder display deficits in decision\u2010making in the Iowa Gambling Task. The rat Gambling Task (rGT) is a rodent analogue that can be used to investigate the neurobiological mechanisms underlying gambling behaviour. The aim of this explorative study was to examine individual strategies in the rGT and investigate possible behavioural and neural correlates associated with gambling strategies. Thirty\u2010two adult male Lister hooded rats underwent behavioural testing in the multivariate concentric square field\u2122 (MCSF) and the novel cage tests, were trained on and performed the rGT and subsequently underwent resting\u2010state functional magnetic resonance imaging (R\u2010fMRI). In the rGT, stable gambling strategies were found with subgroups of rats that preferred the suboptimal safest choice as well as the disadvantageous choice, that is, the riskiest gambling strategy. R\u2010fMRI results revealed associations between gambling strategies and brain regions central for reward networks. Moreover, rats with risky gambling strategies differed from those with strategic and intermediate strategies in brain functional connectivity. No differences in behavioural profiles, as assessed with the MCSF and novel cage tests, were observed between the gambling strategy groups. In conclusion, stable individual differences in gambling strategies were found. Intrinsic functional connectivity using R\u2010fMRI provides novel evidence to support the notion that individual differences in gambling strategies are associated with functional connectivity in brain regions important for reward networks.<\/jats:p>","DOI":"10.1111\/adb.13131","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T03:25:32Z","timestamp":1642476332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional connectivity in reward\u2010related networks is associated with individual differences in gambling strategies in male Lister hooded rats"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-5220","authenticated-orcid":false,"given":"Nikita","family":"Tjernstr\u00f6m","sequence":"first","affiliation":[{"name":"Research Group Neuropharmacology, Addiction and Behavior, Department of Pharmaceutical Biosciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie\u2010Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Medical Radiation and Nuclear Medicine Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-8289","authenticated-orcid":false,"given":"Erika","family":"Roman","sequence":"additional","affiliation":[{"name":"Research Group Neuropharmacology, Addiction and Behavior, Department of Pharmaceutical Biosciences Uppsala University  Uppsala Sweden"},{"name":"Department of Anatomy, Physiology and Biochemistry Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1556\/2006.5.2016.073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.10.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12112"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1702969"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952991003721118"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12378"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(94)90018-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2016.08.012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00665"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.01.017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.07.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00109"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.62"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5597-10.2011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0094-17.2017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4696-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.10.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0534-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112188"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.11.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.04.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082052"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.10.020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.08.020"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00089"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000036"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00236"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20875"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0230-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.035"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120345"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00141.2010"},{"key":"e_1_2_10_36_1","unstructured":"ArtsJW.Effects of reversing light\u2010dark cycle following transfer and re\u2010housing on behavioural and physiological parameters in rats. In Transportation in Laboratory Rats: Effects of a Black Box. Dissertation. Utrecht University: Utrecht University Repository.https:\/\/dspace.library.uu.nl\/handle\/1874\/331183. Published online2016."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_10_38_1","unstructured":"R Core Team.R: a language and environment for statistical computing. R Foundation for Statistical Computing;2018.http:\/\/www.R-project.org\/"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v050.i12"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbbs.2013.34035"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2021.107333"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.080"},{"key":"e_1_2_10_43_1","volume-title":"Paxinos and Watson's The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2014"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140045"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033457"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(04)62006-X"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.geb.2004.06.010"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12951"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112668"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000372"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109830"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00742"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00174"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.10.006"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.06.008"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.01.002"},{"key":"e_1_2_10_58_1","unstructured":"SierakowiakA.Experimental magnetic resonance imaging modalities as tools to evaluate brain function structure and networks: exercise and cocaine induced adaptations. Published online2015."},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21183"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.058"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.11.042"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00503"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.04.022"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0393-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2857-z"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2822-x"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/10731911211004741"},{"key":"e_1_2_10_68_1","volume-title":"Iowa Gambling Task Professional Manual","author":"Bechara A","year":"2007"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029929"}],"updated-by":[{"DOI":"10.1111\/adb.13384","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000}}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T08:42:30Z","timestamp":1705912950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/adb.13131"],"URL":"https:\/\/doi.org\/10.1111\/adb.13131","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/adb.13384","asserted-by":"object"}]},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"2021-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13131"}}