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We have previously reported elevated oxycodone seeking after drug self\u2010administration in rats that received repeated blast TBI (rbTBI). TBI and exposure to drugs of abuse can each change structural and functional neuroimaging outcomes, but it is unknown if there are interactive effects of injury and drug exposure. To determine the effects of TBI and oxycodone exposure, we subjected rats to rbTBI and oxycodone self\u2010administration and measured drug seeking and several neuroimaging measures. We found interactive effects of rbTBI and oxycodone on fractional anisotropy (FA) in the nucleus accumbens (NAc) and that FA in the medial prefrontal cortex (mPFC) was correlated with drug seeking. We also found an interactive effect of injury and drug on widespread functional connectivity and regional homogeneity of the blood oxygen level dependent (BOLD) response, and that intra\u2010hemispheric functional connectivity in the infralimbic medial prefrontal cortex positively correlated with drug seeking. In conclusion, rbTBI and oxycodone self\u2010administration had interactive effects on structural and functional magnetic resonance imaging (MRI) measures, and correlational effects were found between some of these measures and drug seeking. These data support the hypothesis that TBI and opioid exposure produce neuroadaptations that contribute to addiction liability.<\/jats:p>","DOI":"10.1111\/adb.13134","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T20:37:18Z","timestamp":1642538238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Repeated blast mild traumatic brain injury and oxycodone self\u2010administration produce interactive effects on neuroimaging outcomes"],"prefix":"10.1111","volume":"27","author":[{"given":"Matthew J.","family":"Muelbl","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breanna L.","family":"Glaeser","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Neuroscience Research Center Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Clement J. 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