{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:29:12Z","timestamp":1787689752419,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010232","name":"National Institute of Development Administration","doi-asserted-by":"publisher","award":["DA02812"],"award-info":[{"award-number":["DA02812"]}],"id":[{"id":"10.13039\/501100010232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of \u2018microdosing\u2019. Thousands of users claim that very low doses of LSD, taken at 3\u20134\u2010day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double\u2010blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26\u2009\u03bcg) or placebo, administered to healthy adults at 3\u20134\u00a0day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N\u2009=\u200918), 13\u2009\u03bcg LSD (N\u2009=\u200919), or 26\u2009\u03bcg LSD (N\u2009=\u200919). They attended four 5\u2010hour drug\u2010administration sessions separated by 3\u20134\u00a0days, followed by a drug\u2010free follow\u2010up session 3\u20134\u00a0days after the last session. LSD (26\u2009\u03bcg) produced modest subjective effects including increased ratings of \u2018feeling a drug effect\u2019 and both stimulant\u2010like and LSD\u2010like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug\u2010free follow\u2010up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.<\/jats:p>","DOI":"10.1111\/adb.13143","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T23:48:54Z","timestamp":1643759334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Repeated low doses of LSD in healthy adults: A placebo\u2010controlled, dose\u2013response study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-8994","authenticated-orcid":false,"given":"Harriet","family":"de Wit","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-4512","authenticated-orcid":false,"given":"Hanna M.","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Bershad","sequence":"additional","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bremmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royce","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral 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