{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:12:37Z","timestamp":1780751557545,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["8020\u201000110B"],"award-info":[{"award-number":["8020\u201000110B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA027825"],"award-info":[{"award-number":["DA027825"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ligands that stimulate muscarinic acetylcholine receptors 1 and 4 (M\n                    <jats:sub>1<\/jats:sub>\n                    , M\n                    <jats:sub>4<\/jats:sub>\n                    ) have shown promising effects as putative pharmacotherapy for cocaine use disorder in rodent assays. We have previously shown reductions in cocaine effects with acute M\n                    <jats:sub>4<\/jats:sub>\n                    stimulation, as well as long\u2010lasting, delayed reductions in cocaine taking and cocaine seeking with combined M\n                    <jats:sub>1<\/jats:sub>\n                    \/M\n                    <jats:sub>4<\/jats:sub>\n                    receptor stimulation or with M\n                    <jats:sub>1<\/jats:sub>\n                    stimulation alone. M\n                    <jats:sub>4<\/jats:sub>\n                    stimulation opposes dopaminergic signalling acutely, but direct dopamine receptor antagonists have proved unhelpful in managing cocaine use disorder because they lose efficacy with long\u2010term administration. It is therefore critical to determine whether M\n                    <jats:sub>4<\/jats:sub>\n                    approaches themselves can remain effective with repeated or chronic dosing. We assessed the effects of repeated administration of the M\n                    <jats:sub>4<\/jats:sub>\n                    positive allosteric modulator (PAM) VU0152099 in rats trained to choose between intravenous cocaine and a liquid food reinforcer to obtain quantitative measurement of whether M\n                    <jats:sub>4<\/jats:sub>\n                    stimulation could produce delayed and lasting reduction in cocaine taking. VU0152099 produced progressively augmenting suppression of cocaine choice and cocaine intake, but produced neither rebound nor lasting effects after treatment ended. To compare and contrast effects of M\n                    <jats:sub>1<\/jats:sub>\n                    versus M\n                    <jats:sub>4<\/jats:sub>\n                    stimulation, we tested whether the M\n                    <jats:sub>4<\/jats:sub>\n                    PAM VU0152100 suppressed cocaine self\u2010administration in mice lacking CalDAG\u2010GEFI signalling factor, required for M\n                    <jats:sub>1<\/jats:sub>\n                    \u2010mediated suppression of cocaine self\u2010administration. CalDAG\u2010GEFI ablation had no effect on M\n                    <jats:sub>4<\/jats:sub>\n                    \u2010mediated suppression of cocaine self\u2010administration. These findings support the potential usefulness of M\n                    <jats:sub>4<\/jats:sub>\n                    PAMs as pharmacotherapy to manage cocaine use disorder, alone or in combination with M\n                    <jats:sub>1<\/jats:sub>\n                    \u2010selective ligands, and show that M\n                    <jats:sub>1<\/jats:sub>\n                    and M\n                    <jats:sub>4<\/jats:sub>\n                    stimulation modulate cocaine\u2010taking behaviour by distinct mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/adb.13145","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:33:50Z","timestamp":1643142830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of acute and repeated administration of the selective M\n                    <sub>4<\/sub>\n                    PAM VU0152099 on cocaine versus food choice in male rats"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-6006","authenticated-orcid":false,"given":"Morgane","family":"Thomsen","sequence":"first","affiliation":[{"name":"Neuroscience and Behavioral Pharmacology Laboratory, Alcohol and Drug Abuse Research Center, Division of Basic Research McLean Hospital\/Harvard Medical School  Belmont Massachusetts USA"},{"name":"Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen Mental Health Services in the Capital Region of Denmark  Copenhagen Denmark"},{"name":"Department of Neuroscience, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-1917","authenticated-orcid":false,"given":"Jill R.","family":"Crittenden","sequence":"additional","affiliation":[{"name":"McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0168-1445","authenticated-orcid":false,"given":"Craig W.","family":"Lindsley","sequence":"additional","affiliation":[{"name":"Vanderbilt Program in Drug Discovery, Vanderbilt Specialized Chemistry Center (Molecular Libraries Probe Production Centers Network; MLPCN), Department of Pharmacology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-7720","authenticated-orcid":false,"given":"Ann M.","family":"Graybiel","sequence":"additional","affiliation":[{"name":"McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1532"},{"key":"e_1_2_9_3_1","unstructured":"EMCDDA.European Drug Report 2018.2018."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.08.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.04.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283428cd8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2005.00992.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2011.00130.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2019.08.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172758"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11669"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2020.01.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2019.05.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890130408"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2016-0028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90655-F"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1999.tb00082.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEMN.0000012718.08443.60"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00142-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3256-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0684-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4797-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2751-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.03.014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.140350"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"CrittendenJR SauvageM KitsukawaT et al.Mutations in CalDAG\u2010GEFI lead to striatal signaling deficits and psychomotor symptoms in multiple species including human. Biorxviv.2019.","DOI":"10.1101\/709246"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.241141"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.162057"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeab.15"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.11.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0378-z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.07.013"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0281-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.016"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01910-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.11.029"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5620-09.2010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.09.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2516-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.039"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500003z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2225-4"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.10.050"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112649"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00139"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3843-09.2010"},{"key":"e_1_2_9_49_1","first-page":"576","article-title":"Differential effects of the 5\u2010HT2A receptor antagonist M100,907 and the 5\u2010HT2C receptor antagonist SB242,084 on cocaine\u2010induced locomotor activity, cocaine self\u2010administration and cocaine\u2010induced reinstatement of responding","volume":"27","author":"Fletcher PJ","year":"2002","journal-title":"Neuropharmacology"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0197-y"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00461"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T03:41:33Z","timestamp":1705894893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/adb.13145"],"URL":"https:\/\/doi.org\/10.1111\/adb.13145","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.06.459176","asserted-by":"object"}]},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"2021-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13145"}}