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Humans report compulsive patterns of bath salts use, and previous work suggests that a subset of rats develop unusually high levels of MDPV self\u2010administration. This study aims to test the hypothesis that high levels of impulsivity (e.g., inability to withhold responding for a sucrose reward) will predispose rats to high levels of MDPV self\u2010administration relative to rats with lower levels of impulsivity. The 1\u2010choice serial reaction time task (1\u2010CSRTT) was used to assess impulsivity (i.e., premature responding) in 10 female and 10 male Sprague Dawley rats. Rats were then allowed to self\u2010administer 0.032\u2009mg\/kg\/inf MDPV or 0.32\u2009mg\/kg\/inf cocaine, after which full dose\u2013response curves for MDPV (0.001\u20130.1\u00a0mg\/kg\/inf) or cocaine (0.01\u20131\u00a0mg\/kg\/inf) were generated under a FR5 schedule of reinforcement. After a history of self\u2010administering MDPV or cocaine, impulsivity was reassessed under the 1\u2010CSRTT, prior to evaluating the acute effects of MDPV (0.032\u20130.32\u2009mg\/kg) or cocaine (0.1\u20131\u00a0mg\/kg) on impulsivity. Level of impulsivity was not correlated with subsequent levels of either MDPV or cocaine self\u2010administration, and level of drug self\u2010administration was also not correlated with subsequent levels of impulsivity, although acute administration of MDPV and cocaine did increase premature responding. In failing to find direct relationships between either impulsivity and subsequent drug\u2010taking behaviour, or drug\u2010taking behaviour and subsequent assessments of impulsivity, these findings highlight the complexity inherent in the associations between impulsive behaviour and drug\u2010taking behaviour in both animal models and humans.<\/jats:p>","DOI":"10.1111\/adb.13168","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T02:57:19Z","timestamp":1647917839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Interactions between impulsivity and MDPV self\u2010administration in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Megan S.","family":"Abbott","sequence":"first","affiliation":[{"name":"Department of Pharmacology The University of Texas Health Science Center at San Antonio  San Antonio Texas 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