{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:28:23Z","timestamp":1790652503061,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sleep problems and substance use frequently co\u2010occur. While substance use can result in specific sleep deficits, genetic pleiotropy could explain part of the relationship between sleep and substance use and use disorders. Here we use the largest publicly available genome\u2010wide summary statistics of substance use behaviours (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200979,729\u2013632,802) and sleep\/activity phenotypes to date (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200985,502\u2013449,734) to (1) assess the genetic overlap between substance use behaviours and both sleep and circadian\u2010related activity measures, (2) estimate clusters from genetic correlations and (3) test processes of causality versus genetic pleiotropy. We found 31 genetic correlations between substance use and sleep\/activity after Bonferroni correction. These patterns of overlap were represented by two genetic clusters: (1) tobacco use severity (age of first regular tobacco use and smoking cessation) and sleep health (sleep duration, sleep efficiency and chronotype) and (2) substance consumption\/problematic use (drinks per day and cigarettes per day, cannabis use disorder, opioid use disorder and problematic alcohol use) and sleep problems (insomnia, self\u2010reported short sleep duration, increased number of sleep episodes, increased sleep duration variability and diurnal inactivity) and measures of circadian\u2010related activity (L5, M10 and sleep midpoint). Latent causal variable analyses determined that horizontal pleiotropy (rather than genetic causality) underlies a majority of the associations between substance use and sleep\/circadian related measures, except one plausible genetically causal relationship for opioid use disorder on self\u2010reported long sleep duration. Results show that shared genetics are likely a mechanism that is at least partly responsible for the overlap between sleep and substance use traits.\n                  <\/jats:p>","DOI":"10.1111\/adb.13184","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T19:09:36Z","timestamp":1653851376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterisation\u00a0of the genetic relationship between the domains of sleep and circadian\u2010related behaviours\u00a0with substance use phenotypes"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-7267","authenticated-orcid":false,"given":"Alexander S.","family":"Hatoum","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  Saint Louis Missouri 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