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However, little is known about their willingness to consume other addictive drugs. Here, we examined (a) whether the HDID\u20101 and HDID\u20102 lines of mice would voluntarily consume midazolam, methamphetamine, morphine and nicotine in a DID test and (b) whether the HDID lines differ from their founders, heterogeneous stock\/Northport (HS\/NPT), in consumption levels of these drugs at the concentrations tested. Separate groups of HDID\u20101, HDID\u20102 and HS\/NPT mice were given 4\u2009days of access to each drug, using the single\u2010bottle, limited\u2010access DID paradigm. Male and female mice of both HDID lines consumed all four offered drugs. We observed no genotype differences in 40\u2009\u03bcg\/ml methamphetamine intake, but significant differences in nicotine, midazolam and morphine intake. Both HDID lines drank significantly more (150\u2009\u03bcg\/ml) midazolam than their founders, providing strong support for a shared genetic contribution to binge ethanol and midazolam intake. HDID\u20102 mice, but not HDID\u20101 mice, consumed more morphine (700\u2009\u03bcg\/ml) and more nicotine across a range of concentrations than HS\/NPT mice. These results demonstrate that the HDID mice can be utilized for tests of voluntary drug consumption other than ethanol and highlight potentially important differences between HDID lines in risk for elevated drug intake.<\/jats:p>","DOI":"10.1111\/adb.13212","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:43:15Z","timestamp":1660095795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Midazolam, methamphetamine, morphine and nicotine intake in high\u2010drinking\u2010in\u2010the\u2010dark mice"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-2324","authenticated-orcid":false,"given":"Antonia M.","family":"Savarese","sequence":"first","affiliation":[{"name":"Portland Alcohol Research Center, Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland 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